FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068209188> ?p ?o ?g. }

• W2068209188 endingPage "98" @default.
• W2068209188 startingPage "90" @default.
• W2068209188 abstract "In view of the cardioprotective effect of high-density lipoproteins (HDL) and the limited effects of statin and fibrate therapy on HDL cholesterol, it is clinically relevant to test whether pharmacological treatment aimed at raising HDL lowers cardiovascular risk. Cholesteryl ester transfer protein (CETP) is a new therapeutic target, because the cholesteryl ester transfer process lowers HDL cholesterol and contributes to an atherogenic lipoprotein profile, particularly when plasma triglycerides are high. Clinical evidence suggests that coronary artery calcification as well as intima media thickness is positively related to plasma cholesteryl ester transfer, and that high plasma CETP concentration is associated with increased cardiovascular risk in hypertriglyceridaemia. However, CETP could also have anti-atherogenic potential, since it provides a potentially beneficial route for delivery of HDL-derived cholesteryl esters to the liver. In addition, CETP could also favourably stimulate peripheral cell cholesterol removal and enhance hepatic cholesterol uptake. Recent evidence suggests that a high CETP level may confer lower cardiovascular risk in the context of low triglycerides. At maximal doses, the CETP inhibitors JTT-705 and torcetrapib elicit a marked rise in HDL cholesterol of up to 34% and 91-106%, respectively. The effectiveness of these drugs on (intermediate) clinical outcome measures is currently being tested in large-scale phase III clinical trials, with torcetrapib being only evaluated in combination therapy with atorvastatin. When and how to use CETP inhibitors, e.g. in combination with a statin or a fibrate, is a major challenge. We propose that low HDL cholesterol in the context of high triglycerides, such as found in type 2 diabetes mellitus, could become an important indication area for this new class of drugs." @default.
• W2068209188 created "2016-06-24" @default.
• W2068209188 creator A5037520101 @default.
• W2068209188 creator A5041851398 @default.
• W2068209188 creator A5060583173 @default.
• W2068209188 creator A5060728967 @default.
• W2068209188 date "2007-01-04" @default.
• W2068209188 modified "2023-10-14" @default.
• W2068209188 title "CETP inhibition in cardiovascular risk management: a critical appraisal" @default.
• W2068209188 cites W1528960277 @default.
• W2068209188 cites W1626021976 @default.
• W2068209188 cites W1947043095 @default.
• W2068209188 cites W1968498359 @default.
• W2068209188 cites W1979080082 @default.
• W2068209188 cites W1984236807 @default.
• W2068209188 cites W1988448764 @default.
• W2068209188 cites W1993775410 @default.
• W2068209188 cites W1998091483 @default.
• W2068209188 cites W1998187767 @default.
• W2068209188 cites W2002922298 @default.
• W2068209188 cites W2003671495 @default.
• W2068209188 cites W2007342896 @default.
• W2068209188 cites W2012613681 @default.
• W2068209188 cites W2013731962 @default.
• W2068209188 cites W2014137262 @default.
• W2068209188 cites W2017062359 @default.
• W2068209188 cites W2020659754 @default.
• W2068209188 cites W2024445165 @default.
• W2068209188 cites W2048360969 @default.
• W2068209188 cites W2052624323 @default.
• W2068209188 cites W2053540100 @default.
• W2068209188 cites W2055596216 @default.
• W2068209188 cites W2058670466 @default.
• W2068209188 cites W2061941384 @default.
• W2068209188 cites W2065641536 @default.
• W2068209188 cites W2069610898 @default.
• W2068209188 cites W2070721554 @default.
• W2068209188 cites W2077760013 @default.
• W2068209188 cites W2078679613 @default.
• W2068209188 cites W2084336658 @default.
• W2068209188 cites W2093648180 @default.
• W2068209188 cites W2095801584 @default.
• W2068209188 cites W2100632362 @default.
• W2068209188 cites W2101777997 @default.
• W2068209188 cites W2102768269 @default.
• W2068209188 cites W2111482014 @default.
• W2068209188 cites W2114689977 @default.
• W2068209188 cites W2115870892 @default.
• W2068209188 cites W2117416880 @default.
• W2068209188 cites W2118624524 @default.
• W2068209188 cites W2119862574 @default.
• W2068209188 cites W2120094394 @default.
• W2068209188 cites W2123842908 @default.
• W2068209188 cites W2126816601 @default.
• W2068209188 cites W2127625944 @default.
• W2068209188 cites W2130581607 @default.
• W2068209188 cites W2131620609 @default.
• W2068209188 cites W2131885674 @default.
• W2068209188 cites W2134930063 @default.
• W2068209188 cites W2138301203 @default.
• W2068209188 cites W2144625678 @default.
• W2068209188 cites W2147912052 @default.
• W2068209188 cites W2148609678 @default.
• W2068209188 cites W2148635162 @default.
• W2068209188 cites W2151720705 @default.
• W2068209188 cites W2153066298 @default.
• W2068209188 cites W2155937325 @default.
• W2068209188 cites W2159274928 @default.
• W2068209188 cites W2165711645 @default.
• W2068209188 cites W2166033139 @default.
• W2068209188 cites W2166606079 @default.
• W2068209188 cites W2167542744 @default.
• W2068209188 cites W2320293912 @default.
• W2068209188 cites W4243503137 @default.
• W2068209188 cites W4244668309 @default.
• W2068209188 cites W4245409061 @default.
• W2068209188 cites W4362068863 @default.
• W2068209188 cites W818906334 @default.
• W2068209188 doi "https://doi.org/10.1111/j.1365-2362.2007.01756.x" @default.
• W2068209188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17217373" @default.
• W2068209188 hasPublicationYear "2007" @default.
• W2068209188 type Work @default.
• W2068209188 sameAs 2068209188 @default.
• W2068209188 citedByCount "50" @default.
• W2068209188 countsByYear W20682091882012 @default.
• W2068209188 countsByYear W20682091882013 @default.
• W2068209188 countsByYear W20682091882015 @default.
• W2068209188 countsByYear W20682091882016 @default.
• W2068209188 countsByYear W20682091882017 @default.
• W2068209188 countsByYear W20682091882018 @default.
• W2068209188 countsByYear W20682091882019 @default.
• W2068209188 countsByYear W20682091882020 @default.
• W2068209188 countsByYear W20682091882021 @default.
• W2068209188 countsByYear W20682091882023 @default.
• W2068209188 crossrefType "journal-article" @default.
• W2068209188 hasAuthorship W2068209188A5037520101 @default.
• W2068209188 hasAuthorship W2068209188A5041851398 @default.
• W2068209188 hasAuthorship W2068209188A5060583173 @default.

• next