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- W2068211750 abstract "Prolactinomas were diagnosed in four patients with primary amenorrhea and five patients with primary oligomenorrhea. The patients were 18–27 years old with a mean of 22 years. All patients had normal pubarche and thelarche with galactorrhea in only one patient. Serum prolactin levels were higher in patients with primary amenorrhea than those with primary oligomenorrhea (146–1770 ng/mL, 41.4–317 ng/mL, respectively). Baseline serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), human growth hormone (HGH), and cortisol were normal. Four patients showed deficient HGH and cortisol response to insulin-induced hypoglycemia, and three patients showed normal response. All patients showed normal TSH response to TRH stimulation. The response of LH and FSH was normal in four of five patients. All patients showed deficient prolactin response to TRH stimulation. The use of bromocriptine was effective in normalizing serum prolactin levels in six patients. Two patients failed to respond to bromocriptine, suggesting some degree of unresponsiveness of these tumors associated with primary amenorrhea." @default.
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- W2068211750 date "1991-01-01" @default.
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- W2068211750 title "Primary amenorrhea-oligomenorrhea due to prolactinomas in adolescent and adult girls" @default.
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