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• W2068224188 abstract "Plexins are receptors implicated in mediating signaling by semaphorins, a family of axonal chemorepellents. The role of specific plexins in mediating semaphorin function in vivo has not, however, yet been examined in vertebrates. Here, we show that plexin-A3 is the most ubiquitously expressed plexin family member within regions of the developing mammalian nervous system known to contain semaphorin-responsive neurons. Using a chimeric receptor construct, we provide evidence that plexin-A3 can transduce a repulsive signal in growth cones in vitro. Analysis of plexin-A3 knockout mice shows that plexin-A3 contributes to Sema3F and Sema3A signaling and that plexin-A3 regulates the development of hippocampal axonal projections in vivo." @default.
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• W2068224188 date "2001-10-01" @default.
• W2068224188 modified "2023-10-16" @default.
• W2068224188 title "Plexin-A3 Mediates Semaphorin Signaling and Regulates the Development of Hippocampal Axonal Projections" @default.
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• W2068224188 doi "https://doi.org/10.1016/s0896-6273(01)00478-0" @default.
• W2068224188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11683995" @default.
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