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• W2068226345 abstract "Summary Intracutaneous nerve growth factor reduces the activity-dependent slowing of conduction of the mechano-insensitive C-fibers. This long-term change of axonal characteristics might contribute to hyperalgesia. Parts of this study have been published in abstract form (Obreja et al., Society for Neuroscience Meeting, 2008, Washington, 668.5). Nerve growth factor (NGF) induces acute sensitization of nociceptive sensory endings and long-lasting hyperalgesia. NGF modulation of sodium channel expression might contribute to neurotrophin-induced hyperalgesia. Here, we investigated NGF-evoked changes of the activity-dependent slowing of conduction in porcine C-fibers. Animals received intradermal injections of NGF (2 μg or 8 μg) or saline in both hind limbs. Extracellular recordings from the saphenous nerves were performed 1 week later. Based on sensory thresholds and electrically induced activity-dependent slowing (ADS) of axonal conduction, C-fibers were classified as mechano-sensitive afferents, mechano-insensitive afferents, cold nociceptors, and sympathetic efferents. NGF (2 μg) increased conduction velocity in C-fibers from 1.0 ± 0.05 m/s to 1.2 ± 0.07 m/s. In mechano-insensitive afferents, NGF (8 μg) reduced activity-dependent slowing of conduction, from 5.3 ± 0.2% to 3.2 ± 0.5% (0.125–0.5 Hz stimulation) and from 28.5 ± 1.3% to 20.9 ± 1.9% (2 Hz stimulation), such that ADS no longer differentiated between mechano-sensitive and mechano-insensitive fibers. Accordingly, the number of fibers with pronounced ADS decreased but more units with pronounced ADS were mechano-sensitive. Spontaneously active C-fibers were increased above the control level (1%) by NGF 8 μg (8%). The results demonstrate that NGF changes the functional axonal characteristics of mechano-insensitive C-fibers and enhances spontaneous activity thereby possibly contributing to hyperalgesia." @default.
• W2068226345 created "2016-06-24" @default.
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• W2068226345 date "2011-09-01" @default.
• W2068226345 modified "2023-10-17" @default.
• W2068226345 title "Nerve growth factor selectively decreases activity-dependent conduction slowing in mechano-insensitive C-nociceptors" @default.
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• W2068226345 doi "https://doi.org/10.1016/j.pain.2011.05.021" @default.
• W2068226345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21763072" @default.
• W2068226345 hasPublicationYear "2011" @default.
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