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• W2068227947 abstract "During skeletal muscle differentiation, a subset of myoblasts remains quiescent and undifferentiated but retains the capacity to self-renew and give rise to differentiating myoblasts [1Kitzmann M. Carnac G. Vandromme M. Primig M. Lamb N.J.C. Fernandez A. The muscle regulatory factors MyoD and Myf-5 undergo distinct cell cycle-specific expression in muscle cells.J Cell Biol. 1998; 142: 1447-1459Crossref PubMed Scopus (240) Google Scholar, 2Lindon C. Montarras D. Pinset C. Cell cycle-regulated expression of the muscle determination factor Myf-5 in proliferating myoblasts.J Cell Biol. 1998; 140: 111-118Crossref PubMed Scopus (95) Google Scholar, 3Yoshida N. Yoshida S. Koishi K. Masuda K. Nabeshima Y. Cell heterogeneity upon myogenic differentiation: down-regulation of MyoD and Myf-5 generates “reserve cells”.J Cell Sci. 1998; 111: 769-779Crossref PubMed Google Scholar]: this sub-population of muscle cells was recently termed ‘reserve cells’ [3Yoshida N. Yoshida S. Koishi K. Masuda K. Nabeshima Y. Cell heterogeneity upon myogenic differentiation: down-regulation of MyoD and Myf-5 generates “reserve cells”.J Cell Sci. 1998; 111: 769-779Crossref PubMed Google Scholar]. In order to characterise genes that can regulate the ratio between reserve cells and differentiating myoblasts, we examined members of the retinoblastoma tumor suppressor family — Rb, p107 and p130 — an important family of negative regulators of E2F transcription factors and cell cycle progression [4Mulligan G. Jacks T. The retinoblastoma gene family: cousins with overlapping interests.Trends Genet. 1998; 14: 223-228Abstract Full Text Full Text PDF PubMed Scopus (274) Google Scholar]. Although pRb and p107 positively regulate muscle cell differentiation [5Gu W. Schneider J.W. Condorelly G. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation.Cell. 1993; 72: 309-324Abstract Full Text PDF PubMed Scopus (635) Google Scholar, 6Schneider J.W. GU W. Zhu L. Mahdavi V. Nadal-Ginard B. Reversal of terminal differentiation mediated by p107 in Rb–/– muscle cells.Science. 1994; 264: 1467-1471Crossref PubMed Scopus (335) Google Scholar, 7Zacksenhaus E. Jiang Z. Ghung D. Marth J.D. Phillips R.A. Gallie B.L. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.Genes Dev. 1996; 10: 3051-3064Crossref PubMed Scopus (261) Google Scholar], the role of p130 in muscle cells remains unknown. We show here that p130 (protein and mRNA), but neither pRb nor p107, preferentially accumulates during muscle differentiation in reserve cells. Also, p130 is the major Rb-family protein present in E2F complexes in this sub-population of cells. Although forced expression of either p130 or pRb in mouse C2 myoblasts efficiently blocked cell cycle progression, only p130 inhibited the differentiation program. Furthermore, muscle cells overexpressing p130 had reduced levels of the muscle-promoting factor MyoD. In addition, p130 repressed the transactivation capacity of MyoD, an effect abolished by co-transfection of pRb. Thus, we propose that p130, by blocking cell cycle progression and differentiation, could be part of a specific pathway that defines a pool of reserve cells during terminal differentiation." @default.
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• W2068227947 date "2000-05-01" @default.
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• W2068227947 title "The retinoblastoma-like protein p130 is involved in the determination of reserve cells in differentiating myoblasts" @default.
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• W2068227947 doi "https://doi.org/10.1016/s0960-9822(00)00471-1" @default.
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