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- W2068235536 abstract "Normal aging disrupts hippocampal neuroplasticity and learning and memory. Aging deficits were exposed in a subset (30%) of middle-aged mice that performed below criterion on a hippocampal-dependent contextual fear conditioning task. Basal neuronal excitability was comparable in middle-aged and young mice, but learning-related modulation of the post-burst afterhyperpolarization (AHP)--a general mechanism engaged during learning--was impaired in CA1 neurons from middle-aged weak learners. Thus, modulation of neuronal excitability is critical for retention of context fear in middle-aged mice. Disruption of AHP plasticity may contribute to contextual fear deficits in middle-aged mice--a model of age-associated cognitive decline (AACD)." @default.
- W2068235536 created "2016-06-24" @default.
- W2068235536 creator A5033108105 @default.
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- W2068235536 date "2009-05-26" @default.
- W2068235536 modified "2023-10-04" @default.
- W2068235536 title "Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice" @default.
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- W2068235536 doi "https://doi.org/10.1101/lm.1365609" @default.
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