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- W2068235574 startingPage "30" @default.
- W2068235574 abstract "Conjugated linoleic acid (CLA) consists of a group of naturally occurring and synthetic positional and geomet- ric (cis-trans) stereoisomers of the polyunsaturated fatty acid linoleic acid. The cis-9,trans-11 (c9,t11) CLA isomer (the most prevalent form found in ruminant-derived foods) and the trans-10,cis-12 (t10,c12) CLA isomer (present in commer- cial preparations) are the two most widely studied CLA isomers in breast cancer. Studies using both animal and cell cul- ture models indicate that these CLA isomers, when added to the diet or included in the cell culture medium, inhibit mam- mary tumour initiation, promotion and progression in rodents, and alter tumour cell viability in vitro. The mechanism of CLA's anticancer effect is not well understood, but may involve interference with the cell cycle, induction of apoptosis, modulation of gene expression via the activation of peroxisome proliferator-activated receptors, lipid peroxidation, modu- lation of the tumour microenvironment, changes to the structure and/or function of the cell membrane, and interference with growth factor receptor signaling. A greater understanding of the mechanism of action of CLA will support the devel- opment of clinical trials to evaluate the potential effectiveness of CLA in the treatment of breast cancer." @default.
- W2068235574 created "2016-06-24" @default.
- W2068235574 creator A5000588670 @default.
- W2068235574 creator A5003569859 @default.
- W2068235574 creator A5007880547 @default.
- W2068235574 date "2010-01-01" @default.
- W2068235574 modified "2023-09-27" @default.
- W2068235574 title "The Role of Conjugated Linoleic Acid in Breast Cancer Growth and Development" @default.
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