FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068241485> ?p ?o ?g. }

• W2068241485 endingPage "1514" @default.
• W2068241485 startingPage "1508" @default.
• W2068241485 abstract "Background and Purpose— Molecular imaging of therapeutic interventions with targeted agents that simultaneously carry drugs or genes for local delivery is appealing. We investigated the ability of a novel microbubble carrier (immunobubble) for abciximab, a glycoprotein IIb/IIIa receptor inhibitor, for ultrasonographic molecular imaging of human clots. Methods— Human thrombi were incubated with immunobubbles conjugated with abciximab. Control clots were incubated in either saline or with immunobubbles conjugated with nonspecific antibody. We evaluated immunobubble suspensions with variable concentrations of encapsulated gas and measured mean acoustic intensity of the incubated clots. In vivo molecular imaging of human thrombi with abciximab immunobubbles was evaluated in a rat model of carotid artery occlusion. Results— Mean acoustic intensity was significantly higher for abciximab immunobubbles as compared with control immunobubbles under all conditions tested with maximum difference in intensity at a gas volume of 0.2 μL ( P =0.0013 for mechanical index 0.05, P =0.0001 for mechanical index 0.7). Binding of abciximab immunobubbles to clots in vitro led to enhanced echogenicity dependent on bubble concentration. In vivo ultrasonic detectability of carotid thrombi was significantly higher for clots targeted with abciximab immunobubbles ( P <0.05). Quantification of in vivo contrast enhancement displayed a highly significant increment for abciximab immunobubble-targeted clots compared with nonspecific immunobubble-targeted clots ( P <0.0001) and to native clots ( P <0.0001). Conclusions— This study demonstrates the feasibility of using a therapeutic agent for selective targeting in vascular imaging. Abciximab immunobubbles improve visualization of human clots both in vitro and in an in vivo model of acute arterial thrombotic occlusion." @default.
• W2068241485 created "2016-06-24" @default.
• W2068241485 creator A5006146050 @default.
• W2068241485 creator A5025087607 @default.
• W2068241485 creator A5038430255 @default.
• W2068241485 creator A5057843713 @default.
• W2068241485 creator A5060002230 @default.
• W2068241485 creator A5071263301 @default.
• W2068241485 creator A5073863901 @default.
• W2068241485 creator A5075838906 @default.
• W2068241485 creator A5087421542 @default.
• W2068241485 creator A5089756794 @default.
• W2068241485 date "2007-05-01" @default.
• W2068241485 modified "2023-10-16" @default.
• W2068241485 title "Molecular Imaging of Human Thrombus With Novel Abciximab Immunobubbles and Ultrasound" @default.
• W2068241485 cites W1989308172 @default.
• W2068241485 cites W2000417464 @default.
• W2068241485 cites W2003076472 @default.
• W2068241485 cites W2011766727 @default.
• W2068241485 cites W2012618710 @default.
• W2068241485 cites W2015182475 @default.
• W2068241485 cites W2021669011 @default.
• W2068241485 cites W2029033870 @default.
• W2068241485 cites W2067879263 @default.
• W2068241485 cites W2079260436 @default.
• W2068241485 cites W2104736983 @default.
• W2068241485 cites W2129370487 @default.
• W2068241485 cites W2143162872 @default.
• W2068241485 cites W2171579609 @default.
• W2068241485 cites W2226388796 @default.
• W2068241485 cites W2407998854 @default.
• W2068241485 cites W2467187168 @default.
• W2068241485 doi "https://doi.org/10.1161/strokeaha.106.471391" @default.
• W2068241485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17379828" @default.
• W2068241485 hasPublicationYear "2007" @default.
• W2068241485 type Work @default.
• W2068241485 sameAs 2068241485 @default.
• W2068241485 citedByCount "116" @default.
• W2068241485 countsByYear W20682414852012 @default.
• W2068241485 countsByYear W20682414852013 @default.
• W2068241485 countsByYear W20682414852014 @default.
• W2068241485 countsByYear W20682414852015 @default.
• W2068241485 countsByYear W20682414852016 @default.
• W2068241485 countsByYear W20682414852017 @default.
• W2068241485 countsByYear W20682414852018 @default.
• W2068241485 countsByYear W20682414852019 @default.
• W2068241485 countsByYear W20682414852020 @default.
• W2068241485 countsByYear W20682414852021 @default.
• W2068241485 countsByYear W20682414852022 @default.
• W2068241485 countsByYear W20682414852023 @default.
• W2068241485 crossrefType "journal-article" @default.
• W2068241485 hasAuthorship W2068241485A5006146050 @default.
• W2068241485 hasAuthorship W2068241485A5025087607 @default.
• W2068241485 hasAuthorship W2068241485A5038430255 @default.
• W2068241485 hasAuthorship W2068241485A5057843713 @default.
• W2068241485 hasAuthorship W2068241485A5060002230 @default.
• W2068241485 hasAuthorship W2068241485A5071263301 @default.
• W2068241485 hasAuthorship W2068241485A5073863901 @default.
• W2068241485 hasAuthorship W2068241485A5075838906 @default.
• W2068241485 hasAuthorship W2068241485A5087421542 @default.
• W2068241485 hasAuthorship W2068241485A5089756794 @default.
• W2068241485 hasBestOaLocation W20682414851 @default.
• W2068241485 hasConcept C126322002 @default.
• W2068241485 hasConcept C126838900 @default.
• W2068241485 hasConcept C136229726 @default.
• W2068241485 hasConcept C136339569 @default.
• W2068241485 hasConcept C143753070 @default.
• W2068241485 hasConcept C150903083 @default.
• W2068241485 hasConcept C207001950 @default.
• W2068241485 hasConcept C26291073 @default.
• W2068241485 hasConcept C2777871224 @default.
• W2068241485 hasConcept C2781362458 @default.
• W2068241485 hasConcept C45393284 @default.
• W2068241485 hasConcept C500558357 @default.
• W2068241485 hasConcept C71924100 @default.
• W2068241485 hasConcept C86803240 @default.
• W2068241485 hasConceptScore W2068241485C126322002 @default.
• W2068241485 hasConceptScore W2068241485C126838900 @default.
• W2068241485 hasConceptScore W2068241485C136229726 @default.
• W2068241485 hasConceptScore W2068241485C136339569 @default.
• W2068241485 hasConceptScore W2068241485C143753070 @default.
• W2068241485 hasConceptScore W2068241485C150903083 @default.
• W2068241485 hasConceptScore W2068241485C207001950 @default.
• W2068241485 hasConceptScore W2068241485C26291073 @default.
• W2068241485 hasConceptScore W2068241485C2777871224 @default.
• W2068241485 hasConceptScore W2068241485C2781362458 @default.
• W2068241485 hasConceptScore W2068241485C45393284 @default.
• W2068241485 hasConceptScore W2068241485C500558357 @default.
• W2068241485 hasConceptScore W2068241485C71924100 @default.
• W2068241485 hasConceptScore W2068241485C86803240 @default.
• W2068241485 hasIssue "5" @default.
• W2068241485 hasLocation W20682414851 @default.
• W2068241485 hasLocation W20682414852 @default.
• W2068241485 hasOpenAccess W2068241485 @default.
• W2068241485 hasPrimaryLocation W20682414851 @default.
• W2068241485 hasRelatedWork W1964738369 @default.
• W2068241485 hasRelatedWork W2042078353 @default.
• W2068241485 hasRelatedWork W2043117219 @default.

• next