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- W2068243493 abstract "The susceptibility of human papillomavirus infection to polyclonal human leukocyte interferon (IFN-α) has been evaluated in patients with epidermodysplasia verruciformis (EV), a disease with extensive chronic papillomavirus-induced warts. In a double-blind, placebo-controlled study with intralesional IFN-α, four of five IFN-α-treated warts regressed; none of the placebo-treated warts responded (p = 0.024). Three patients with EV were treated with systemic IFN-α for 4 weeks in an open study, achieving partial regression of warts in all three. In a double-blind, placebo-controlled study, warts in two children with EV regressed with systemic IFN-α while two who received placebo showed no improvement. The lesions recurred following cessation of Therapy. At the completion of therapy with IFN-α, histologic normalization was accompanied by a 95% decrease in the number of viral antigen-containing cells in the warts (p < 0.001). We conclude that warts in EV respond to systemic and intralesional IFN-α. The susceptibility of human papillomavirus infection to polyclonal human leukocyte interferon (IFN-α) has been evaluated in patients with epidermodysplasia verruciformis (EV), a disease with extensive chronic papillomavirus-induced warts. In a double-blind, placebo-controlled study with intralesional IFN-α, four of five IFN-α-treated warts regressed; none of the placebo-treated warts responded (p = 0.024). Three patients with EV were treated with systemic IFN-α for 4 weeks in an open study, achieving partial regression of warts in all three. In a double-blind, placebo-controlled study, warts in two children with EV regressed with systemic IFN-α while two who received placebo showed no improvement. The lesions recurred following cessation of Therapy. At the completion of therapy with IFN-α, histologic normalization was accompanied by a 95% decrease in the number of viral antigen-containing cells in the warts (p < 0.001). We conclude that warts in EV respond to systemic and intralesional IFN-α." @default.
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- W2068243493 date "1984-08-01" @default.
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- W2068243493 title "Response of warts in epidermodysplasia verruciformis to treatment with systemic and intralesional alpha interferon" @default.
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- W2068243493 doi "https://doi.org/10.1016/s0190-9622(84)70149-6" @default.
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