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- W2068250655 abstract "Background: Nuclear factor-kappa B (NF-κB), which is regulated by inhibitor of NF-κB kinase (IKK), plays a critical role in the development of myocarditis. However, little is known about the role of IKK in its pathophysiology. We assessed the hypothesis that IKK inhibition could attenuate cardiac inflammation in the progression of myocarditis. Materials and Methods: We administered the IKK inhibitor (IMD-0354, 15mg/kg/day) to experimental autoimmune myocarditis (EAM) rats daily (n=6). The drug-free vehicle was used as control (n=6). Echocardiogram revealed that the IKK inhibitor improved left ventricular fractional shortening in comparison to the untreated group (p<0.05). Non-treated EAM hearts demonstrated an increased heart per body weight ratio, the IKK inhibitor administration significantly reduced the ratio (p<0.05). Pathologically, severe myocardial cell infiltration was observed in the non-treated group, while the IKK inhibitor treatment significantly suppressed these changes. Immunohistochemistry revealed that the numbers of CD4 and CD8 positive infiltrating cells increased in the untreated group, while there were fewer of these cells in the IKK inhibitor treated group. Conclusion: The IKK inhibitor suppressed myocardial inflammation and fibrosis through the attenuation of inflammatory cell migration. Thus, the IKK inhibitor may be useful for the suppression of myocardial remodeling after acute myocarditis." @default.
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- W2068250655 date "2010-09-01" @default.
- W2068250655 modified "2023-10-18" @default.
- W2068250655 title "The Inhibitor of NF-κB Kinase Plays a Pivotal Role in the Development of Autoimmune Myocarditis in Rats" @default.
- W2068250655 doi "https://doi.org/10.1016/j.cardfail.2010.07.147" @default.
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