FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068255192> ?p ?o ?g. }

• W2068255192 endingPage "1235" @default.
• W2068255192 startingPage "1205" @default.
• W2068255192 abstract "The methodology for generating a homology model of the T1 TCR-PbCS-Kd class I major histocompatibility complex (MHC) class I complex is presented. The resulting model provides a qualitative explanation of the effect of over 50 different mutations in the region of the complementarity determining region (CDR) loops of the T cell receptor (TCR), the peptide and the MHC’s α1/α2 helices. The peptide is modified by an azido benzoic acid photoreactive group, which is part of the epitope recognized by the TCR. The construction of the model makes use of closely related homologs (the A6 TCR-Tax-HLA A2 complex, the 2C TCR, the 14.3.d TCR Vβ chain, the 1934.4 TCR Vα chain, and the H-2 Kb-ovalbumine peptide), ab initio sampling of CDR loops conformations and experimental data to select from the set of possibilities. The model shows a complex arrangement of the CDR3α, CDR1β, CDR2β and CDR3β loops that leads to the highly specific recognition of the photoreactive group. The protocol can be applied systematically to a series of related sequences, permitting the analysis at the structural level of the large TCR repertoire specific for a given peptide-MHC complex." @default.
• W2068255192 created "2016-06-24" @default.
• W2068255192 creator A5009968141 @default.
• W2068255192 creator A5039715549 @default.
• W2068255192 creator A5076499540 @default.
• W2068255192 date "2000-07-01" @default.
• W2068255192 modified "2023-09-29" @default.
• W2068255192 title "Modeling of the TCR-MHC-peptide complex11Edited by J. Thornton" @default.
• W2068255192 cites W1483381170 @default.
• W2068255192 cites W1491345809 @default.
• W2068255192 cites W1508885706 @default.
• W2068255192 cites W1514760836 @default.
• W2068255192 cites W1541258411 @default.
• W2068255192 cites W1548757996 @default.
• W2068255192 cites W1574312817 @default.
• W2068255192 cites W1606011614 @default.
• W2068255192 cites W1967798275 @default.
• W2068255192 cites W1970312342 @default.
• W2068255192 cites W1971477120 @default.
• W2068255192 cites W1996621120 @default.
• W2068255192 cites W2000908837 @default.
• W2068255192 cites W2002992883 @default.
• W2068255192 cites W2004607866 @default.
• W2068255192 cites W2013238066 @default.
• W2068255192 cites W2013829952 @default.
• W2068255192 cites W2018002124 @default.
• W2068255192 cites W2018849234 @default.
• W2068255192 cites W2021351245 @default.
• W2068255192 cites W2022950330 @default.
• W2068255192 cites W2024027822 @default.
• W2068255192 cites W2025786614 @default.
• W2068255192 cites W2027189612 @default.
• W2068255192 cites W2027408247 @default.
• W2068255192 cites W2027638447 @default.
• W2068255192 cites W2034100527 @default.
• W2068255192 cites W2036221425 @default.
• W2068255192 cites W2043080692 @default.
• W2068255192 cites W2046375526 @default.
• W2068255192 cites W2050253058 @default.
• W2068255192 cites W2054154028 @default.
• W2068255192 cites W2055738243 @default.
• W2068255192 cites W2065283382 @default.
• W2068255192 cites W2068448872 @default.
• W2068255192 cites W2071486470 @default.
• W2068255192 cites W2074534136 @default.
• W2068255192 cites W2081119016 @default.
• W2068255192 cites W2086783533 @default.
• W2068255192 cites W2088502819 @default.
• W2068255192 cites W2092002806 @default.
• W2068255192 cites W2092249806 @default.
• W2068255192 cites W2094186244 @default.
• W2068255192 cites W2097382368 @default.
• W2068255192 cites W2100959610 @default.
• W2068255192 cites W2104011738 @default.
• W2068255192 cites W2112194058 @default.
• W2068255192 cites W2126679079 @default.
• W2068255192 cites W2131363383 @default.
• W2068255192 cites W2148812183 @default.
• W2068255192 cites W2150345297 @default.
• W2068255192 cites W2153957501 @default.
• W2068255192 cites W2155740919 @default.
• W2068255192 cites W2162166182 @default.
• W2068255192 cites W2168885089 @default.
• W2068255192 cites W4241855343 @default.
• W2068255192 cites W4248012512 @default.
• W2068255192 cites W4248064674 @default.
• W2068255192 cites W4250753748 @default.
• W2068255192 cites W4313376832 @default.
• W2068255192 doi "https://doi.org/10.1006/jmbi.2000.3788" @default.
• W2068255192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10903865" @default.
• W2068255192 hasPublicationYear "2000" @default.
• W2068255192 type Work @default.
• W2068255192 sameAs 2068255192 @default.
• W2068255192 citedByCount "30" @default.
• W2068255192 countsByYear W20682551922012 @default.
• W2068255192 countsByYear W20682551922013 @default.
• W2068255192 countsByYear W20682551922014 @default.
• W2068255192 countsByYear W20682551922015 @default.
• W2068255192 countsByYear W20682551922016 @default.
• W2068255192 countsByYear W20682551922017 @default.
• W2068255192 countsByYear W20682551922018 @default.
• W2068255192 countsByYear W20682551922019 @default.
• W2068255192 countsByYear W20682551922020 @default.
• W2068255192 countsByYear W20682551922021 @default.
• W2068255192 crossrefType "journal-article" @default.
• W2068255192 hasAuthorship W2068255192A5009968141 @default.
• W2068255192 hasAuthorship W2068255192A5039715549 @default.
• W2068255192 hasAuthorship W2068255192A5076499540 @default.
• W2068255192 hasConcept C104317684 @default.
• W2068255192 hasConcept C147483822 @default.
• W2068255192 hasConcept C167625842 @default.
• W2068255192 hasConcept C185592680 @default.
• W2068255192 hasConcept C19317047 @default.
• W2068255192 hasConcept C195616568 @default.
• W2068255192 hasConcept C207936829 @default.
• W2068255192 hasConcept C2776090121 @default.
• W2068255192 hasConcept C2779281246 @default.
• W2068255192 hasConcept C54355233 @default.

• next