Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068256856> ?p ?o ?g. }
- W2068256856 endingPage "1922" @default.
- W2068256856 startingPage "1916" @default.
- W2068256856 abstract "Anemia linked to a relative deficiency of renal erythropoietin production is a significant cause of morbidity and medical expenditures in the developed world. Recombinant erythropoietin is expensive and has been linked to excess cardiovascular events. Moreover, some patients become refractory to erythropoietin because of increased production of factors such as hepcidin. During fetal life, the liver, rather than the kidney, is the major source of erythropoietin. In the present study, we show that it is feasible to reactivate hepatic erythropoietin production and suppress hepcidin levels using systemically delivered siRNAs targeting the EglN prolyl hydroxylases specifically in the liver, leading to improved RBC production in models of anemia caused by either renal insufficiency or chronic inflammation with enhanced hepcidin production." @default.
- W2068256856 created "2016-06-24" @default.
- W2068256856 creator A5000330352 @default.
- W2068256856 creator A5009974215 @default.
- W2068256856 creator A5019401898 @default.
- W2068256856 creator A5035036670 @default.
- W2068256856 creator A5036827827 @default.
- W2068256856 creator A5060331261 @default.
- W2068256856 creator A5065218265 @default.
- W2068256856 creator A5073063612 @default.
- W2068256856 creator A5077685566 @default.
- W2068256856 creator A5078610354 @default.
- W2068256856 creator A5088456751 @default.
- W2068256856 date "2012-08-30" @default.
- W2068256856 modified "2023-09-26" @default.
- W2068256856 title "Treatment of erythropoietin deficiency in mice with systemically administered siRNA" @default.
- W2068256856 cites W1964756939 @default.
- W2068256856 cites W1965209932 @default.
- W2068256856 cites W1965933415 @default.
- W2068256856 cites W1966147820 @default.
- W2068256856 cites W1967145414 @default.
- W2068256856 cites W1970233364 @default.
- W2068256856 cites W1973313690 @default.
- W2068256856 cites W1982628508 @default.
- W2068256856 cites W1988377666 @default.
- W2068256856 cites W1992933063 @default.
- W2068256856 cites W2005438156 @default.
- W2068256856 cites W2005973637 @default.
- W2068256856 cites W2011629202 @default.
- W2068256856 cites W2018008610 @default.
- W2068256856 cites W2023245037 @default.
- W2068256856 cites W2034565548 @default.
- W2068256856 cites W2035855731 @default.
- W2068256856 cites W2050830271 @default.
- W2068256856 cites W2052201224 @default.
- W2068256856 cites W2058062704 @default.
- W2068256856 cites W2060104085 @default.
- W2068256856 cites W2060221489 @default.
- W2068256856 cites W2062341564 @default.
- W2068256856 cites W2064266243 @default.
- W2068256856 cites W2065083959 @default.
- W2068256856 cites W2073389555 @default.
- W2068256856 cites W2082411854 @default.
- W2068256856 cites W2083249633 @default.
- W2068256856 cites W2087098834 @default.
- W2068256856 cites W2089150369 @default.
- W2068256856 cites W2091689719 @default.
- W2068256856 cites W2095151181 @default.
- W2068256856 cites W2095793094 @default.
- W2068256856 cites W2097654747 @default.
- W2068256856 cites W2103553099 @default.
- W2068256856 cites W2110083155 @default.
- W2068256856 cites W2116374020 @default.
- W2068256856 cites W2125319175 @default.
- W2068256856 cites W2129346144 @default.
- W2068256856 cites W2132503585 @default.
- W2068256856 cites W2135827580 @default.
- W2068256856 cites W2136732413 @default.
- W2068256856 cites W2143743183 @default.
- W2068256856 cites W2149173548 @default.
- W2068256856 cites W2152815385 @default.
- W2068256856 cites W2157705760 @default.
- W2068256856 cites W2160800237 @default.
- W2068256856 cites W2169978547 @default.
- W2068256856 cites W4243766541 @default.
- W2068256856 doi "https://doi.org/10.1182/blood-2012-04-423715" @default.
- W2068256856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3433093" @default.
- W2068256856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22611156" @default.
- W2068256856 hasPublicationYear "2012" @default.
- W2068256856 type Work @default.
- W2068256856 sameAs 2068256856 @default.
- W2068256856 citedByCount "41" @default.
- W2068256856 countsByYear W20682568562012 @default.
- W2068256856 countsByYear W20682568562013 @default.
- W2068256856 countsByYear W20682568562014 @default.
- W2068256856 countsByYear W20682568562015 @default.
- W2068256856 countsByYear W20682568562016 @default.
- W2068256856 countsByYear W20682568562017 @default.
- W2068256856 countsByYear W20682568562018 @default.
- W2068256856 countsByYear W20682568562019 @default.
- W2068256856 countsByYear W20682568562020 @default.
- W2068256856 countsByYear W20682568562021 @default.
- W2068256856 countsByYear W20682568562022 @default.
- W2068256856 crossrefType "journal-article" @default.
- W2068256856 hasAuthorship W2068256856A5000330352 @default.
- W2068256856 hasAuthorship W2068256856A5009974215 @default.
- W2068256856 hasAuthorship W2068256856A5019401898 @default.
- W2068256856 hasAuthorship W2068256856A5035036670 @default.
- W2068256856 hasAuthorship W2068256856A5036827827 @default.
- W2068256856 hasAuthorship W2068256856A5060331261 @default.
- W2068256856 hasAuthorship W2068256856A5065218265 @default.
- W2068256856 hasAuthorship W2068256856A5073063612 @default.
- W2068256856 hasAuthorship W2068256856A5077685566 @default.
- W2068256856 hasAuthorship W2068256856A5078610354 @default.
- W2068256856 hasAuthorship W2068256856A5088456751 @default.
- W2068256856 hasBestOaLocation W20682568561 @default.
- W2068256856 hasConcept C126322002 @default.
- W2068256856 hasConcept C134018914 @default.