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- W2068262452 abstract "Tricyclic antidepressants are not for everyone. Because some depressed persons do not respond to these drugs at all or have severe adverse reactions, certain discarded treatments for depression are again finding favor, while new ones proliferate. Monoamine oxidase inhibitors [MAOIs] have been looked at askance, for example, but they will probably be coming back more and more, says Jan Fawcett, MD, chief of psychiatry at Rush-Presbyterian-St Luke's Medical Center in Chicago. They didn't seem efficacious in early studies—the dosages in those studies were too low—but in higher dosages they appear to be very effective for many patients who do not respond to tricyclics. Newer pharmacotherapies include a spate of chemicals tested widely in Europe and elsewhere but minimally in the United States, such as the tetracyclics which are popular in England. For the most part, these drugs have proved no more efficacious than tricyclics and are equally toxic" @default.
- W2068262452 created "2016-06-24" @default.
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- W2068262452 date "1980-04-18" @default.
- W2068262452 modified "2023-09-25" @default.
- W2068262452 title "Beyond tricyclics: outlook on antidepressive treatments" @default.
- W2068262452 doi "https://doi.org/10.1001/jama.1980.03300410003001" @default.
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