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- W2068270983 abstract "As is observed clinically, cessation of chronic clodine in the rat results in a syndrome characterized by sympathetic hyperactivity. After three weeks of chronic oral administration, tyrosine hydroxylase (TOH) activity was unchanged in superior cervival ganglia and locus coeruleus, but was reduced (45%) in the celiac ganglia. Abrupt cessation of treatment resulted in increases in TOH activity in superior cervical and celiac ganglia (to 135 and 250% of controls) and in the locus coerrules (170% of control). These data suggest a selective effect of clonidine treatment and withdrawal on vasomoto fibers. A mechanism explaining physical dependence on clonidine is proposed." @default.
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- W2068270983 title "Effect of chronic clonidine treatment and withdrwal on tyrosine hydroxylase activity in peripheral ganglia and the locus coeruleus" @default.
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- W2068270983 doi "https://doi.org/10.1016/0014-2999(78)90418-1" @default.
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