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- W2068271344 abstract "Abstract: To investigate the influence of GABAergic function on seizure development, the effects of bicuculline, a GABAa receptor antagonist, on visual cortical and hippocampal kindling were examined in chronically prepared rabbits. Kindling-inducing stimulations were repeated at 5-min intervals. The changes in afterdischarge (AD) durations were compared before and 30 min after a low (2 mg/kg) and high dose (5 mg/kg) i.p. injection of bicuculline solution. In the visual cortical kindling group, the AD durations were markedly shortened after the low dose bicuculline injection, while bicuculline produced a prolongation of the AD durations in the visual cortical with the high dose injection and hippocampal kindling groups. The low dose bicuculline-induced inhibition of visual cortical kindling suggests facilitative GABAergic action on seizure development, while the drug-induced enhancement in the other groups reflects the well-known inhibitory GABAergic action." @default.
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- W2068271344 date "1993-09-01" @default.
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- W2068271344 title "Paradoxical GABAergic Facilitation on Seizure Development Observed from Bicuculline-Induced Effects on Visual Cortical Kindling at Short Interstimulus Intervals in Chronically Prepared Rabbits" @default.
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- W2068271344 doi "https://doi.org/10.1111/j.1440-1819.1993.tb01816.x" @default.
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