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- W2068271736 abstract "We studied theophylline elimination in 8 patients with chronic renal failure to determine the effect of hemodialysis on the pharmacokinetics of theophylline. Each subject was studied twice, once on a nondialysis day and again during dialysis. Total body theophylline clearance on the nondialysis day was similar to that reported for patients with normal renal function (57.4 +/- 27.2 ml/kg/h). Hemodialysis accelerated theophylline elimination and shortened serum theophylline half-life in all patients (nondialysis t 1/2 = 7.3 h +/- 2.3 vs. dialysis t 1/2 = 2.7 +/- 0.9 h, p less than 0.01). Dialysis clearance averaged 59.7 +/- 16.4 ml/kg/h with a fraction of drug removed of 0.4 liters in 4 h. Guidelines for theophylline management during hemodialysis are suggested." @default.
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- W2068271736 date "1982-01-01" @default.
- W2068271736 modified "2023-10-12" @default.
- W2068271736 title "Effect of Hemodialysis on the Pharmacokinetics of Theophylline in Chronic Renal Failure" @default.
- W2068271736 doi "https://doi.org/10.1159/000182729" @default.
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