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• W2068273044 abstract "Several disorders are known to be associated with altered Thelper1/Thelper2 (TH1/TH2) cytokine balance. Psoriasis is characterized by increased systemic and local production of TH1 and pro-inflammatory cytokines. Furthermore recent data indicate the dominant presence of TH1 lymphocytes in the circulation and TH1 and Tcytotoxic1 (TC1) cells in lesional skin of psoriatic patients. In order to assess the systemic TH1/TH2 imbalance in psoriasis most of the studies so far tested isolated peripheral mononuclear cells. As a new approach we applied a whole blood flow cytometric assay to determine the rate of circulating TH1/TH2 and TC1/Tcytotoxic2 (TC2) lymphocytes based on their intracellular IFN-γ, IL-4 and IL-10 expression. Besides, serum levels of these cytokines were determined in healthy controls and psoriatic patients by commercial ELISAs. In psoriatic patients we found significantly (P<0.02) increased rates of CD4+/IFN-γ+ lymphocytes (30.3±8.8%) while the percent of CD4+/IL-4+ cells (0.37±0.31%) were significantly (P<0.03) lower compared to healthy controls (CD4+/IFN-γ+: 20.1±7.3% and CD4+/IL-4+: 0.78±0.44%). The IL-10-positive CD4+ and CD8+ cells also had higher rate in psoriasis, but the difference between patients and controls was not significant, similarly to the rate of CD8+/IFN-γ+ and CD8+/IL-4+ lymphocytes. Beside cellular expression, serum IFN-γ levels were also significantly higher (control: 4.9±6.4 pg/ml; psoriatic patients: 35.9±47.0 pg/ml; P<0.05). Our results provide further evidence for an altered TH1/TH2 balance in psoriasis measured in non-separated whole blood T cells." @default.
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• W2068273044 date "2003-05-01" @default.
• W2068273044 modified "2023-10-14" @default.
• W2068273044 title "Elevated rate of Thelper1 (TH1) lymphocytes and serum IFN-γ levels in psoriatic patients" @default.
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• W2068273044 doi "https://doi.org/10.1016/s0165-2478(03)00025-7" @default.
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