Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068274902> ?p ?o ?g. }
- W2068274902 endingPage "119" @default.
- W2068274902 startingPage "111" @default.
- W2068274902 abstract "Astrocytes located in two distinct regions of midbrain differ in their neuritic growth support abilities. Midbrain neurons cultured onto astrocyte monolayers from the lateral (L) region develop long and branched neurites while neurons cultured onto astrocyte monolayers from the medial (M) region develop short or no neurites. The extracellular matrix of these astrocytes has an important role in promoting or inhibiting the growth of these neurons. Differences on the compartmental distribution, as well as on the concentration of GAGs of L and M astrocytes, may be related to their differential capacity of supporting neuritic growth. Indeed, enzymatic digestion of heparan sulfate (HS) and chondroitin sulfate (CS) chains also pointed to an important function for GAGs on axon navigation. In order to better characterize the role of CS on the growth of midbrain neurites, we treated L and M astrocyte monolayers with 1 mM of beta-D-xyloside. Under these conditions, astrocytes oversynthesized and secreted CS protein-free chains to the culture medium. M astrocytes had a significant reduction in their neuritic growth-inhibiting ability after xyloside treatment, suggesting a promoting role for soluble CS in neuritic growth. Chondroitin 4-sulfate (CS-4) added in different concentrations to M astrocyte cultures turned this glia into a permissive substrate, acting in a linear way as far as the largest neurite was concerned. However, a U-shaped dose-effect curve on neurite growth resulted from the similar treatment of L astrocytes. These results suggest that glial CS-4 could be involved in the neurite growth modulating properties of midbrain neurons in a complex concentration-dependent way." @default.
- W2068274902 created "2016-06-24" @default.
- W2068274902 creator A5012548123 @default.
- W2068274902 creator A5013015314 @default.
- W2068274902 creator A5044275719 @default.
- W2068274902 creator A5054635069 @default.
- W2068274902 creator A5084587095 @default.
- W2068274902 date "2003-05-01" @default.
- W2068274902 modified "2023-10-17" @default.
- W2068274902 title "Concentration-dependent actions of glial chondroitin sulfate on the neuritic growth of midbrain neurons" @default.
- W2068274902 cites W1569535372 @default.
- W2068274902 cites W1620623150 @default.
- W2068274902 cites W1824808675 @default.
- W2068274902 cites W1855316532 @default.
- W2068274902 cites W1872912914 @default.
- W2068274902 cites W1965405861 @default.
- W2068274902 cites W1973371244 @default.
- W2068274902 cites W1974823396 @default.
- W2068274902 cites W1978733154 @default.
- W2068274902 cites W1983410669 @default.
- W2068274902 cites W1994469519 @default.
- W2068274902 cites W1997931402 @default.
- W2068274902 cites W1998444924 @default.
- W2068274902 cites W1999778442 @default.
- W2068274902 cites W2005793394 @default.
- W2068274902 cites W2006501418 @default.
- W2068274902 cites W2011858895 @default.
- W2068274902 cites W2012928251 @default.
- W2068274902 cites W2016106167 @default.
- W2068274902 cites W2019730170 @default.
- W2068274902 cites W2023378452 @default.
- W2068274902 cites W2023479786 @default.
- W2068274902 cites W2026965831 @default.
- W2068274902 cites W2036473961 @default.
- W2068274902 cites W2040555595 @default.
- W2068274902 cites W2043143881 @default.
- W2068274902 cites W2045177076 @default.
- W2068274902 cites W2046420755 @default.
- W2068274902 cites W2053491108 @default.
- W2068274902 cites W2064864503 @default.
- W2068274902 cites W2074078925 @default.
- W2068274902 cites W2076732624 @default.
- W2068274902 cites W2082131963 @default.
- W2068274902 cites W2082808714 @default.
- W2068274902 cites W2084713219 @default.
- W2068274902 cites W2089405081 @default.
- W2068274902 cites W2094037670 @default.
- W2068274902 cites W2099134671 @default.
- W2068274902 cites W2105967600 @default.
- W2068274902 cites W2110102431 @default.
- W2068274902 cites W2115577615 @default.
- W2068274902 cites W2118008848 @default.
- W2068274902 cites W2124248841 @default.
- W2068274902 cites W2144286633 @default.
- W2068274902 cites W2150454162 @default.
- W2068274902 cites W2156383601 @default.
- W2068274902 cites W2165475742 @default.
- W2068274902 cites W2168242850 @default.
- W2068274902 cites W2419395528 @default.
- W2068274902 doi "https://doi.org/10.1016/s0165-3806(03)00036-1" @default.
- W2068274902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12711362" @default.
- W2068274902 hasPublicationYear "2003" @default.
- W2068274902 type Work @default.
- W2068274902 sameAs 2068274902 @default.
- W2068274902 citedByCount "17" @default.
- W2068274902 countsByYear W20682749022012 @default.
- W2068274902 countsByYear W20682749022013 @default.
- W2068274902 countsByYear W20682749022014 @default.
- W2068274902 countsByYear W20682749022015 @default.
- W2068274902 countsByYear W20682749022017 @default.
- W2068274902 countsByYear W20682749022021 @default.
- W2068274902 crossrefType "journal-article" @default.
- W2068274902 hasAuthorship W2068274902A5012548123 @default.
- W2068274902 hasAuthorship W2068274902A5013015314 @default.
- W2068274902 hasAuthorship W2068274902A5044275719 @default.
- W2068274902 hasAuthorship W2068274902A5054635069 @default.
- W2068274902 hasAuthorship W2068274902A5084587095 @default.
- W2068274902 hasConcept C113246987 @default.
- W2068274902 hasConcept C153074725 @default.
- W2068274902 hasConcept C169760540 @default.
- W2068274902 hasConcept C189165786 @default.
- W2068274902 hasConcept C202751555 @default.
- W2068274902 hasConcept C2777542381 @default.
- W2068274902 hasConcept C2778041096 @default.
- W2068274902 hasConcept C2779530196 @default.
- W2068274902 hasConcept C2779553658 @default.
- W2068274902 hasConcept C2780884517 @default.
- W2068274902 hasConcept C529278444 @default.
- W2068274902 hasConcept C552161191 @default.
- W2068274902 hasConcept C55493867 @default.
- W2068274902 hasConcept C86803240 @default.
- W2068274902 hasConcept C95444343 @default.
- W2068274902 hasConceptScore W2068274902C113246987 @default.
- W2068274902 hasConceptScore W2068274902C153074725 @default.
- W2068274902 hasConceptScore W2068274902C169760540 @default.
- W2068274902 hasConceptScore W2068274902C189165786 @default.
- W2068274902 hasConceptScore W2068274902C202751555 @default.
- W2068274902 hasConceptScore W2068274902C2777542381 @default.