FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068276977> ?p ?o ?g. }

• W2068276977 endingPage "12356" @default.
• W2068276977 startingPage "12351" @default.
• W2068276977 abstract "The Kv2.1 K(+) channel is highly expressed throughout the brain, where it regulates excitability during periods of high-frequency stimulation. Kv2.1 is unique among Kv channels in that it targets to large surface clusters on the neuronal soma and proximal dendrites. These clusters also form in transfected HEK cells. Following excessive excitatory stimulation, Kv2.1 declusters with an accompanying 20- to 30-mV hyperpolarizing shift in the activation threshold. Although most Kv2.1 channels are clustered, there is a pool of Kv2.1 resident outside of these domains. Using the cell-attached patch clamp technique, we investigated the hypothesis that Kv2.1 activity varies as a function of cell surface location. We found that clustered Kv2.1 channels do not efficiently conduct K(+), whereas the nonclustered channels are responsible for the high threshold delayed rectifier K(+) current typical of Kv2.1. Comparison of gating and ionic currents indicates only 2% of the surface channels conduct, suggesting that the clustered channels still respond to membrane potential changes. Declustering induced via either actin depolymerization or alkaline phosphatase treatment did not increase whole-cell currents. Dephosphorylation resulted in a 25-mV hyperpolarizing shift, whereas actin depolymerization did not alter the activation midpoint. Taken together, these data demonstrate that clusters do not contain high threshold Kv2.1 channels whose voltage sensitivity shifts upon declustering; nor are they a reservoir of nonconducting channels that are activated upon release. On the basis of these findings, we propose unique roles for the clustered Kv2.1 that are independent of K(+) conductance." @default.
• W2068276977 created "2016-06-24" @default.
• W2068276977 creator A5032526996 @default.
• W2068276977 creator A5050053264 @default.
• W2068276977 creator A5070750159 @default.
• W2068276977 date "2010-06-21" @default.
• W2068276977 modified "2023-10-13" @default.
• W2068276977 title "Localization-dependent activity of the Kv2.1 delayed-rectifier K ⁺ channel" @default.
• W2068276977 cites W1937739983 @default.
• W2068276977 cites W1967127459 @default.
• W2068276977 cites W1968408785 @default.
• W2068276977 cites W1970467935 @default.
• W2068276977 cites W1979106875 @default.
• W2068276977 cites W1990843666 @default.
• W2068276977 cites W1996589818 @default.
• W2068276977 cites W2009959265 @default.
• W2068276977 cites W2021797855 @default.
• W2068276977 cites W2023195612 @default.
• W2068276977 cites W2034253733 @default.
• W2068276977 cites W2053487364 @default.
• W2068276977 cites W2055121607 @default.
• W2068276977 cites W2058852344 @default.
• W2068276977 cites W2063256813 @default.
• W2068276977 cites W2078317266 @default.
• W2068276977 cites W2078360969 @default.
• W2068276977 cites W2079762354 @default.
• W2068276977 cites W2080633827 @default.
• W2068276977 cites W2086684841 @default.
• W2068276977 cites W2088639521 @default.
• W2068276977 cites W2092222606 @default.
• W2068276977 cites W2096514941 @default.
• W2068276977 cites W2099949778 @default.
• W2068276977 cites W2109195226 @default.
• W2068276977 cites W2118185015 @default.
• W2068276977 cites W2125041118 @default.
• W2068276977 cites W2129706672 @default.
• W2068276977 cites W2138465627 @default.
• W2068276977 cites W2140271428 @default.
• W2068276977 cites W2151942667 @default.
• W2068276977 cites W2154063634 @default.
• W2068276977 cites W2155920800 @default.
• W2068276977 cites W2158798910 @default.
• W2068276977 cites W2162478231 @default.
• W2068276977 cites W2165897590 @default.
• W2068276977 doi "https://doi.org/10.1073/pnas.1003028107" @default.
• W2068276977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2901471" @default.
• W2068276977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20566856" @default.
• W2068276977 hasPublicationYear "2010" @default.
• W2068276977 type Work @default.
• W2068276977 sameAs 2068276977 @default.
• W2068276977 citedByCount "111" @default.
• W2068276977 countsByYear W20682769772012 @default.
• W2068276977 countsByYear W20682769772013 @default.
• W2068276977 countsByYear W20682769772014 @default.
• W2068276977 countsByYear W20682769772015 @default.
• W2068276977 countsByYear W20682769772016 @default.
• W2068276977 countsByYear W20682769772017 @default.
• W2068276977 countsByYear W20682769772018 @default.
• W2068276977 countsByYear W20682769772019 @default.
• W2068276977 countsByYear W20682769772020 @default.
• W2068276977 countsByYear W20682769772021 @default.
• W2068276977 countsByYear W20682769772022 @default.
• W2068276977 countsByYear W20682769772023 @default.
• W2068276977 crossrefType "journal-article" @default.
• W2068276977 hasAuthorship W2068276977A5032526996 @default.
• W2068276977 hasAuthorship W2068276977A5050053264 @default.
• W2068276977 hasAuthorship W2068276977A5070750159 @default.
• W2068276977 hasBestOaLocation W20682769771 @default.
• W2068276977 hasConcept C112592302 @default.
• W2068276977 hasConcept C11960822 @default.
• W2068276977 hasConcept C12554922 @default.
• W2068276977 hasConcept C147944092 @default.
• W2068276977 hasConcept C169760540 @default.
• W2068276977 hasConcept C170493617 @default.
• W2068276977 hasConcept C178666793 @default.
• W2068276977 hasConcept C181911157 @default.
• W2068276977 hasConcept C181912034 @default.
• W2068276977 hasConcept C185263204 @default.
• W2068276977 hasConcept C185592680 @default.
• W2068276977 hasConcept C194544171 @default.
• W2068276977 hasConcept C24998067 @default.
• W2068276977 hasConcept C50254741 @default.
• W2068276977 hasConcept C55493867 @default.
• W2068276977 hasConcept C86803240 @default.
• W2068276977 hasConcept C94924445 @default.
• W2068276977 hasConceptScore W2068276977C112592302 @default.
• W2068276977 hasConceptScore W2068276977C11960822 @default.
• W2068276977 hasConceptScore W2068276977C12554922 @default.
• W2068276977 hasConceptScore W2068276977C147944092 @default.
• W2068276977 hasConceptScore W2068276977C169760540 @default.
• W2068276977 hasConceptScore W2068276977C170493617 @default.
• W2068276977 hasConceptScore W2068276977C178666793 @default.
• W2068276977 hasConceptScore W2068276977C181911157 @default.
• W2068276977 hasConceptScore W2068276977C181912034 @default.
• W2068276977 hasConceptScore W2068276977C185263204 @default.
• W2068276977 hasConceptScore W2068276977C185592680 @default.
• W2068276977 hasConceptScore W2068276977C194544171 @default.
• W2068276977 hasConceptScore W2068276977C24998067 @default.

• next