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• W2068286031 endingPage "461" @default.
• W2068286031 startingPage "455" @default.
• W2068286031 abstract "Testis cancer is the most frequent solid malignancy in young men. The majority of patients present with clinical stage I disease and about 50% of them are nonseminomatous germ cell tumors. In this initial stage of disease there is a subgroup of patients at high risk with a likelihood of more than 50% for relapse. Treatment options for these patients include: retroperitoneal lymph node dissection (RPLND), albeit 6–10% of patients will relapse outside the field of RPLND, active surveillance with even higher relapse rates and adjuvant chemotherapy. As most of these patients have the chance to become long-term survivors, avoidance of long-term side effects is of utmost importance. This review provides information on the potential of chemotherapy to achieve a higher chance of cure for patients with high-risk clinical stage I disease than its therapeutic alternatives and addresses toxicity and dose dependency." @default.
• W2068286031 created "2016-06-24" @default.
• W2068286031 creator A5037122872 @default.
• W2068286031 creator A5075222976 @default.
• W2068286031 date "2009-07-28" @default.
• W2068286031 modified "2023-09-23" @default.
• W2068286031 title "High-risk clinical stage I nonseminomatous germ cell tumors: the case for chemotherapy" @default.
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• W2068286031 doi "https://doi.org/10.1007/s00345-009-0456-3" @default.
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• W2068286031 hasPublicationYear "2009" @default.
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