FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068287710> ?p ?o ?g. }

• W2068287710 endingPage "798" @default.
• W2068287710 startingPage "792" @default.
• W2068287710 abstract "The gene encoding the Ras-related GTPase RhoB-specific is immediate-early inducible by genotoxic treatments. Regulation of transcriptional activation of rhoB is still unclear. Here we show that cells lacking either p53 or c-Fos are not different from wild-type cells with respect to the level of rhoB induction upon UV irradiation, indicating that these transcription factors are not crucial for stimulation of rhoB mRNA expression. Extracts from UV-irradiated and non-irradiated cells revealed similar DNA-binding activities to a 0.17 kb rhoB promoter fragment harboring the functional element(s) necessary for stimulation of rhoB by UV light. By means of immunoprecipitation we found that an ATF-2-specific antibody co-precipitates the (32)P-labeled 0.17 kb rhoB fragment, whereas an anti-AP1 antibody did not. Since no consensus sequence for binding of ATF-2 is present within the rhoB promoter, ATF-2 is likely to be associated with another factor that binds to the minimal promoter. Deletion analysis and site-directed mutagenesis of the 0.17 kb rhoB fragment revealed a CCAAT box to be an essential requirement for stimulation of rhoB by UV light and methyl methanesulfonate. Moreover, immunoprecipitation experiments showed that the CCAAT-binding factor NF-YA is complexed with ATF-2. Overall, the data strongly indicate that transcriptional activation of the rhoB gene by genotoxic stress is regulated via a CCAAT box and that interaction of CCAAT-binding factor and ATF-2 triggers the stress-inducible expression of rhoB." @default.
• W2068287710 created "2016-06-24" @default.
• W2068287710 creator A5018660823 @default.
• W2068287710 date "2001-02-01" @default.
• W2068287710 modified "2023-10-16" @default.
• W2068287710 title "Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element" @default.
• W2068287710 cites W1516657748 @default.
• W2068287710 cites W1555489233 @default.
• W2068287710 cites W1555964835 @default.
• W2068287710 cites W1665899257 @default.
• W2068287710 cites W1868769527 @default.
• W2068287710 cites W1964633722 @default.
• W2068287710 cites W1965372133 @default.
• W2068287710 cites W1974653642 @default.
• W2068287710 cites W1984903682 @default.
• W2068287710 cites W1987109846 @default.
• W2068287710 cites W2003849027 @default.
• W2068287710 cites W2021253208 @default.
• W2068287710 cites W2026748045 @default.
• W2068287710 cites W2030570585 @default.
• W2068287710 cites W2037128954 @default.
• W2068287710 cites W2037148821 @default.
• W2068287710 cites W2061587634 @default.
• W2068287710 cites W2063588528 @default.
• W2068287710 cites W2075734864 @default.
• W2068287710 cites W2076053303 @default.
• W2068287710 cites W2086624112 @default.
• W2068287710 cites W2099735202 @default.
• W2068287710 cites W2100747076 @default.
• W2068287710 cites W2122321206 @default.
• W2068287710 cites W2128635872 @default.
• W2068287710 cites W2134812217 @default.
• W2068287710 cites W2142638534 @default.
• W2068287710 cites W2155200989 @default.
• W2068287710 cites W2163263222 @default.
• W2068287710 cites W2192757572 @default.
• W2068287710 cites W2232879680 @default.
• W2068287710 cites W2470643593 @default.
• W2068287710 doi "https://doi.org/10.1093/nar/29.3.792" @default.
• W2068287710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/30383" @default.
• W2068287710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11160903" @default.
• W2068287710 hasPublicationYear "2001" @default.
• W2068287710 type Work @default.
• W2068287710 sameAs 2068287710 @default.
• W2068287710 citedByCount "46" @default.
• W2068287710 countsByYear W20682877102012 @default.
• W2068287710 countsByYear W20682877102013 @default.
• W2068287710 countsByYear W20682877102014 @default.
• W2068287710 countsByYear W20682877102015 @default.
• W2068287710 countsByYear W20682877102016 @default.
• W2068287710 countsByYear W20682877102017 @default.
• W2068287710 countsByYear W20682877102018 @default.
• W2068287710 countsByYear W20682877102019 @default.
• W2068287710 countsByYear W20682877102021 @default.
• W2068287710 countsByYear W20682877102023 @default.
• W2068287710 crossrefType "journal-article" @default.
• W2068287710 hasAuthorship W2068287710A5018660823 @default.
• W2068287710 hasBestOaLocation W20682877101 @default.
• W2068287710 hasConcept C101762097 @default.
• W2068287710 hasConcept C104317684 @default.
• W2068287710 hasConcept C150194340 @default.
• W2068287710 hasConcept C153911025 @default.
• W2068287710 hasConcept C179716448 @default.
• W2068287710 hasConcept C2777093181 @default.
• W2068287710 hasConcept C2778917187 @default.
• W2068287710 hasConcept C54355233 @default.
• W2068287710 hasConcept C62478195 @default.
• W2068287710 hasConcept C86339819 @default.
• W2068287710 hasConcept C86803240 @default.
• W2068287710 hasConcept C95444343 @default.
• W2068287710 hasConceptScore W2068287710C101762097 @default.
• W2068287710 hasConceptScore W2068287710C104317684 @default.
• W2068287710 hasConceptScore W2068287710C150194340 @default.
• W2068287710 hasConceptScore W2068287710C153911025 @default.
• W2068287710 hasConceptScore W2068287710C179716448 @default.
• W2068287710 hasConceptScore W2068287710C2777093181 @default.
• W2068287710 hasConceptScore W2068287710C2778917187 @default.
• W2068287710 hasConceptScore W2068287710C54355233 @default.
• W2068287710 hasConceptScore W2068287710C62478195 @default.
• W2068287710 hasConceptScore W2068287710C86339819 @default.
• W2068287710 hasConceptScore W2068287710C86803240 @default.
• W2068287710 hasConceptScore W2068287710C95444343 @default.
• W2068287710 hasIssue "3" @default.
• W2068287710 hasLocation W20682877101 @default.
• W2068287710 hasLocation W20682877102 @default.
• W2068287710 hasLocation W20682877103 @default.
• W2068287710 hasLocation W20682877104 @default.
• W2068287710 hasOpenAccess W2068287710 @default.
• W2068287710 hasPrimaryLocation W20682877101 @default.
• W2068287710 hasRelatedWork W2009966535 @default.
• W2068287710 hasRelatedWork W2039568244 @default.
• W2068287710 hasRelatedWork W2048840805 @default.
• W2068287710 hasRelatedWork W2111182449 @default.
• W2068287710 hasRelatedWork W2121924440 @default.
• W2068287710 hasRelatedWork W2203462220 @default.
• W2068287710 hasRelatedWork W2392370788 @default.
• W2068287710 hasRelatedWork W2460087536 @default.
• W2068287710 hasRelatedWork W2527535582 @default.

• next