Matches in SemOpenAlex for { <https://semopenalex.org/work/W20682879> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W20682879 endingPage "548" @default.
- W20682879 startingPage "548" @default.
- W20682879 abstract "548 Objectives Despite their importance the k-opioid receptors have not been sistematically studied with PET.We employed a recently developed k-agonist tracer([11C]GR103545) and performed a Scatchard study in order to estimate the in vivo receptor concentration Bmax and the dissociation constant Kd. Methods Three rhesus monkeys were scanned with the FOCUS 220:2 of them underwent 2 scans(baseline+self-block), the third was scanned 4 times (2 baseline and 2 self-block at different occupancy levels). A Bolus+Infiusion (B/I) protocol was employed and the cerebellum was used as reference region. Injected masses were 0.042±0.014 ug/Kg at baseline and ranged from 0.17 to 0.3 ug/Kg fro the self-block studies. BPND of all ROIs was computed as [(CROI / CCEREB) -1], CROI and CCEREB being the mean radioactivity concentration from 90 to 120 min in each ROI and in the cerebellum. A standard Scatchard plot was then used to estimate Bmax and Kd,ND=Kd/fND. When Kd,ND was allowed to vary among ROIs, results were very variable; therefore Kd,ND was constrained to be constant across ROIs. Results Bmax ranged from 2 nM to 8 nM with a peak of 15 nM in the putamen; high values were obtained also in cingulate, globus pallidus and insula.Kd,ND was estimated to be 5.85 nM. In addition, Kd, computed as Kd,NDfND was 0.16nM (based on estimates of VND and fP) in good agreement with the in vitro Ki value of 0.33 nM. Percentage standard errors (%SE) were high (>100%) partly due to large intersubject variability. Conclusions The use of a B/I protocol with the k-opioid agonist tracer [11C]GR103545 permitted succesful estimation of Bmax and Kd,ND in vivo." @default.
- W20682879 created "2016-06-24" @default.
- W20682879 creator A5004932337 @default.
- W20682879 creator A5006508700 @default.
- W20682879 creator A5012357230 @default.
- W20682879 creator A5013349320 @default.
- W20682879 creator A5022154603 @default.
- W20682879 creator A5026261851 @default.
- W20682879 creator A5071601991 @default.
- W20682879 creator A5087752085 @default.
- W20682879 creator A5091132069 @default.
- W20682879 date "2009-05-01" @default.
- W20682879 modified "2023-09-24" @default.
- W20682879 title "PET measurements of Bmax and Kd with the k-opioid receptor tracer [11C]GR103545" @default.
- W20682879 hasPublicationYear "2009" @default.
- W20682879 type Work @default.
- W20682879 sameAs 20682879 @default.
- W20682879 citedByCount "0" @default.
- W20682879 crossrefType "journal-article" @default.
- W20682879 hasAuthorship W20682879A5004932337 @default.
- W20682879 hasAuthorship W20682879A5006508700 @default.
- W20682879 hasAuthorship W20682879A5012357230 @default.
- W20682879 hasAuthorship W20682879A5013349320 @default.
- W20682879 hasAuthorship W20682879A5022154603 @default.
- W20682879 hasAuthorship W20682879A5026261851 @default.
- W20682879 hasAuthorship W20682879A5071601991 @default.
- W20682879 hasAuthorship W20682879A5087752085 @default.
- W20682879 hasAuthorship W20682879A5091132069 @default.
- W20682879 hasConcept C121332964 @default.
- W20682879 hasConcept C126322002 @default.
- W20682879 hasConcept C134018914 @default.
- W20682879 hasConcept C170493617 @default.
- W20682879 hasConcept C185592680 @default.
- W20682879 hasConcept C2778187257 @default.
- W20682879 hasConcept C2779714222 @default.
- W20682879 hasConcept C2780278869 @default.
- W20682879 hasConcept C2989005 @default.
- W20682879 hasConcept C46141821 @default.
- W20682879 hasConcept C529278444 @default.
- W20682879 hasConcept C55493867 @default.
- W20682879 hasConcept C71924100 @default.
- W20682879 hasConcept C74998103 @default.
- W20682879 hasConceptScore W20682879C121332964 @default.
- W20682879 hasConceptScore W20682879C126322002 @default.
- W20682879 hasConceptScore W20682879C134018914 @default.
- W20682879 hasConceptScore W20682879C170493617 @default.
- W20682879 hasConceptScore W20682879C185592680 @default.
- W20682879 hasConceptScore W20682879C2778187257 @default.
- W20682879 hasConceptScore W20682879C2779714222 @default.
- W20682879 hasConceptScore W20682879C2780278869 @default.
- W20682879 hasConceptScore W20682879C2989005 @default.
- W20682879 hasConceptScore W20682879C46141821 @default.
- W20682879 hasConceptScore W20682879C529278444 @default.
- W20682879 hasConceptScore W20682879C55493867 @default.
- W20682879 hasConceptScore W20682879C71924100 @default.
- W20682879 hasConceptScore W20682879C74998103 @default.
- W20682879 hasLocation W206828791 @default.
- W20682879 hasOpenAccess W20682879 @default.
- W20682879 hasPrimaryLocation W206828791 @default.
- W20682879 hasRelatedWork W100659466 @default.
- W20682879 hasRelatedWork W159240095 @default.
- W20682879 hasRelatedWork W1595060332 @default.
- W20682879 hasRelatedWork W1984712229 @default.
- W20682879 hasRelatedWork W21257397 @default.
- W20682879 hasRelatedWork W2185930454 @default.
- W20682879 hasRelatedWork W2260157492 @default.
- W20682879 hasRelatedWork W2266807335 @default.
- W20682879 hasRelatedWork W242784414 @default.
- W20682879 hasRelatedWork W2548606139 @default.
- W20682879 hasRelatedWork W2592789076 @default.
- W20682879 hasRelatedWork W2679041406 @default.
- W20682879 hasRelatedWork W2762130809 @default.
- W20682879 hasRelatedWork W2914857578 @default.
- W20682879 hasRelatedWork W3034039495 @default.
- W20682879 hasRelatedWork W3093329435 @default.
- W20682879 hasRelatedWork W3112825870 @default.
- W20682879 hasRelatedWork W3165337414 @default.
- W20682879 hasRelatedWork W3180361801 @default.
- W20682879 hasRelatedWork W3204729284 @default.
- W20682879 hasVolume "50" @default.
- W20682879 isParatext "false" @default.
- W20682879 isRetracted "false" @default.
- W20682879 magId "20682879" @default.
- W20682879 workType "article" @default.