FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068292018> ?p ?o ?g. }

• W2068292018 endingPage "244" @default.
• W2068292018 startingPage "235" @default.
• W2068292018 abstract "In this work, we show that alteration of P407 gel content can affect drug release rates. The inorganic salts and PEG 400 commonly included in the formulation of P407 gels can also change the rate at which a drug is released. Lidocaine was selected as a model drug because, although widely used in the treatment of pain, its use is limited by short duration of its effects. The use of P407 gels prolongs the residence time of the lidocaine at the injection site, sustains drug release and increases therapeutic efficacy. Release studies were performed in a diffusion system. During release, data followed the Higuchi square root law time kinetic (r > 0.98). Increased polymer concentration in the gel increases viscosity and reduces lidocaine release rates and diffusion coefficients via extended gel dissolution time and prolonged drug diffusion through the gel matrix. Lidocaine release rates and diffusion coefficients increased in gels composed of NaCl or PEG 400 aqueous solution. Because these additives are hydrophilic, they reduce gel dissolution time, thereby accelerating drug diffusion. Poloxamer is biocompatible and the results support the possibility of using Poloxamer gel as a sustained release injectable formulation." @default.
• W2068292018 created "2016-06-24" @default.
• W2068292018 creator A5003206246 @default.
• W2068292018 creator A5053612870 @default.
• W2068292018 creator A5075679734 @default.
• W2068292018 creator A5091478720 @default.
• W2068292018 date "2005-01-01" @default.
• W2068292018 modified "2023-10-01" @default.
• W2068292018 title "Sustained release of lidocaine from Poloxamer 407 gels" @default.
• W2068292018 cites W1245876582 @default.
• W2068292018 cites W1498305210 @default.
• W2068292018 cites W1558028925 @default.
• W2068292018 cites W1585527697 @default.
• W2068292018 cites W1598671982 @default.
• W2068292018 cites W1969814091 @default.
• W2068292018 cites W1975771377 @default.
• W2068292018 cites W1987124074 @default.
• W2068292018 cites W1988250258 @default.
• W2068292018 cites W1994999304 @default.
• W2068292018 cites W1995488266 @default.
• W2068292018 cites W1995654243 @default.
• W2068292018 cites W2007543270 @default.
• W2068292018 cites W2020196793 @default.
• W2068292018 cites W2031796501 @default.
• W2068292018 cites W2039733127 @default.
• W2068292018 cites W2054016731 @default.
• W2068292018 cites W2055409818 @default.
• W2068292018 cites W2056255938 @default.
• W2068292018 cites W2058166750 @default.
• W2068292018 cites W2058509094 @default.
• W2068292018 cites W2070752143 @default.
• W2068292018 cites W2075621696 @default.
• W2068292018 cites W2082511674 @default.
• W2068292018 cites W2083771011 @default.
• W2068292018 cites W2084300357 @default.
• W2068292018 cites W2103059492 @default.
• W2068292018 cites W2103730978 @default.
• W2068292018 cites W2104723548 @default.
• W2068292018 cites W2123359760 @default.
• W2068292018 doi "https://doi.org/10.1016/j.ijpharm.2004.09.028" @default.
• W2068292018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15620863" @default.
• W2068292018 hasPublicationYear "2005" @default.
• W2068292018 type Work @default.
• W2068292018 sameAs 2068292018 @default.
• W2068292018 citedByCount "212" @default.
• W2068292018 countsByYear W20682920182012 @default.
• W2068292018 countsByYear W20682920182013 @default.
• W2068292018 countsByYear W20682920182014 @default.
• W2068292018 countsByYear W20682920182015 @default.
• W2068292018 countsByYear W20682920182016 @default.
• W2068292018 countsByYear W20682920182017 @default.
• W2068292018 countsByYear W20682920182018 @default.
• W2068292018 countsByYear W20682920182019 @default.
• W2068292018 countsByYear W20682920182020 @default.
• W2068292018 countsByYear W20682920182021 @default.
• W2068292018 countsByYear W20682920182022 @default.
• W2068292018 countsByYear W20682920182023 @default.
• W2068292018 crossrefType "journal-article" @default.
• W2068292018 hasAuthorship W2068292018A5003206246 @default.
• W2068292018 hasAuthorship W2068292018A5053612870 @default.
• W2068292018 hasAuthorship W2068292018A5075679734 @default.
• W2068292018 hasAuthorship W2068292018A5091478720 @default.
• W2068292018 hasConcept C101335993 @default.
• W2068292018 hasConcept C10138342 @default.
• W2068292018 hasConcept C121332964 @default.
• W2068292018 hasConcept C127413603 @default.
• W2068292018 hasConcept C13245373 @default.
• W2068292018 hasConcept C141071460 @default.
• W2068292018 hasConcept C15920480 @default.
• W2068292018 hasConcept C162324750 @default.
• W2068292018 hasConcept C163588942 @default.
• W2068292018 hasConcept C178790620 @default.
• W2068292018 hasConcept C185592680 @default.
• W2068292018 hasConcept C2779820397 @default.
• W2068292018 hasConcept C2780149897 @default.
• W2068292018 hasConcept C2780306666 @default.
• W2068292018 hasConcept C42360764 @default.
• W2068292018 hasConcept C43617362 @default.
• W2068292018 hasConcept C521977710 @default.
• W2068292018 hasConcept C54400483 @default.
• W2068292018 hasConcept C69357855 @default.
• W2068292018 hasConcept C71924100 @default.
• W2068292018 hasConcept C77281830 @default.
• W2068292018 hasConcept C88380143 @default.
• W2068292018 hasConcept C97355855 @default.
• W2068292018 hasConcept C98274493 @default.
• W2068292018 hasConceptScore W2068292018C101335993 @default.
• W2068292018 hasConceptScore W2068292018C10138342 @default.
• W2068292018 hasConceptScore W2068292018C121332964 @default.
• W2068292018 hasConceptScore W2068292018C127413603 @default.
• W2068292018 hasConceptScore W2068292018C13245373 @default.
• W2068292018 hasConceptScore W2068292018C141071460 @default.
• W2068292018 hasConceptScore W2068292018C15920480 @default.
• W2068292018 hasConceptScore W2068292018C162324750 @default.
• W2068292018 hasConceptScore W2068292018C163588942 @default.
• W2068292018 hasConceptScore W2068292018C178790620 @default.
• W2068292018 hasConceptScore W2068292018C185592680 @default.
• W2068292018 hasConceptScore W2068292018C2779820397 @default.

• next