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• W2068295645 abstract "Caspase activation and degradation of deoxyribonucleic acid (DNA) damage response factors occur during in vitro T-cell proliferation, and an increased frequency of hypoxanthine-guanine phosphoribosyltransferase (HPRT)-negative variants have been reported in conditions associated with in vivo T-cell proliferation. We have applied two human somatic cell mutation reporter assays, for the HPRT and phosphatidylinositol glycan class A (PIG-A) genes, to human T cells activated in vitro with anti-CD3 and anti-CD28. We demonstrate proliferation throughout 6 weeks of cultivation, and find that the frequency of variant cells phenotypically negative for HPRT and PIG-A, respectively, increases from 10−5 up to 10−3–10−2. We also report preliminary evidence for low-density CpG methylation in the HPRT promoter suggesting that epigenetic modification may contribute to this markedly heightened rate of gene inactivation." @default.
• W2068295645 created "2016-06-24" @default.
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• W2068295645 date "2006-12-19" @default.
• W2068295645 modified "2023-10-16" @default.
• W2068295645 title "High rate of mutation reporter gene inactivation during human T cell proliferation" @default.
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• W2068295645 doi "https://doi.org/10.1007/s00251-006-0180-8" @default.
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