Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068296853> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2068296853 endingPage "664" @default.
- W2068296853 startingPage "658" @default.
- W2068296853 abstract "Extensive automation of both random and rational drug discovery strategies greatly increases the number of compounds entering biological screens. Although parallel synthesis (one compound per well) strategies eliminate the deconvolution step necessary when pooled libraries are screened, parallel synthesis products are usually screened as crude mixtures, because purification slows the process of lead discovery. Screening crude products is sometimes complicated by synergies and interferences between compounds. Screening pure compounds is the only sure route to immediate, reliable structure–activity relationships. Automated purification strategies are designed to limit or remove the purification bottleneck between synthesis and screening. In this paper, a workstation is described which uses a combination of UV absorbance and mass spectrometric data to make real-time decisions for HPLC fraction collection, allowing selection of compounds based on mass or substructure. This methodology has demonstrated success with parallel synthesis products in drug discovery applications. © 1998 John Wiley & Sons, Ltd." @default.
- W2068296853 created "2016-06-24" @default.
- W2068296853 creator A5029010569 @default.
- W2068296853 creator A5034910674 @default.
- W2068296853 creator A5045480976 @default.
- W2068296853 creator A5046333348 @default.
- W2068296853 creator A5051112084 @default.
- W2068296853 creator A5064313990 @default.
- W2068296853 creator A5067836178 @default.
- W2068296853 creator A5068349338 @default.
- W2068296853 date "1998-05-29" @default.
- W2068296853 modified "2023-10-07" @default.
- W2068296853 title "Structure-controlled automated purification of parallel synthesis products in drug discovery" @default.
- W2068296853 doi "https://doi.org/10.1002/(sici)1097-0231(19980529)12:10<658::aid-rcm211>3.0.co;2-p" @default.
- W2068296853 hasPublicationYear "1998" @default.
- W2068296853 type Work @default.
- W2068296853 sameAs 2068296853 @default.
- W2068296853 citedByCount "33" @default.
- W2068296853 countsByYear W20682968532014 @default.
- W2068296853 crossrefType "journal-article" @default.
- W2068296853 hasAuthorship W2068296853A5029010569 @default.
- W2068296853 hasAuthorship W2068296853A5034910674 @default.
- W2068296853 hasAuthorship W2068296853A5045480976 @default.
- W2068296853 hasAuthorship W2068296853A5046333348 @default.
- W2068296853 hasAuthorship W2068296853A5051112084 @default.
- W2068296853 hasAuthorship W2068296853A5064313990 @default.
- W2068296853 hasAuthorship W2068296853A5067836178 @default.
- W2068296853 hasAuthorship W2068296853A5068349338 @default.
- W2068296853 hasConcept C127413603 @default.
- W2068296853 hasConcept C149635348 @default.
- W2068296853 hasConcept C183696295 @default.
- W2068296853 hasConcept C185592680 @default.
- W2068296853 hasConcept C21951064 @default.
- W2068296853 hasConcept C2780513914 @default.
- W2068296853 hasConcept C41008148 @default.
- W2068296853 hasConcept C43617362 @default.
- W2068296853 hasConcept C55493867 @default.
- W2068296853 hasConcept C74187038 @default.
- W2068296853 hasConceptScore W2068296853C127413603 @default.
- W2068296853 hasConceptScore W2068296853C149635348 @default.
- W2068296853 hasConceptScore W2068296853C183696295 @default.
- W2068296853 hasConceptScore W2068296853C185592680 @default.
- W2068296853 hasConceptScore W2068296853C21951064 @default.
- W2068296853 hasConceptScore W2068296853C2780513914 @default.
- W2068296853 hasConceptScore W2068296853C41008148 @default.
- W2068296853 hasConceptScore W2068296853C43617362 @default.
- W2068296853 hasConceptScore W2068296853C55493867 @default.
- W2068296853 hasConceptScore W2068296853C74187038 @default.
- W2068296853 hasIssue "10" @default.
- W2068296853 hasLocation W20682968531 @default.
- W2068296853 hasOpenAccess W2068296853 @default.
- W2068296853 hasPrimaryLocation W20682968531 @default.
- W2068296853 hasRelatedWork W1001352512 @default.
- W2068296853 hasRelatedWork W1657880117 @default.
- W2068296853 hasRelatedWork W1769094419 @default.
- W2068296853 hasRelatedWork W1987128138 @default.
- W2068296853 hasRelatedWork W1989889224 @default.
- W2068296853 hasRelatedWork W2595172197 @default.
- W2068296853 hasRelatedWork W2743976221 @default.
- W2068296853 hasRelatedWork W2885125400 @default.
- W2068296853 hasRelatedWork W4382618745 @default.
- W2068296853 hasRelatedWork W2084856301 @default.
- W2068296853 hasVolume "12" @default.
- W2068296853 isParatext "false" @default.
- W2068296853 isRetracted "false" @default.
- W2068296853 magId "2068296853" @default.
- W2068296853 workType "article" @default.