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- W2068298897 abstract "• Increasing intravenous doses of diazepam or placebo were administered to ten healthy normal volunteers, and the changes in saccadic eye velocity, self-rated sedation and anxiety, and plasma cortisol and growth hormone concentrations were measured. Diazepam administration (4.4 to 140 μg/kg, cumulative dose) resulted in a dose-dependent decrease in saccadic eye velocity and plasma cortisol level as well as a dose-dependent increase in self-rated sedation and plasma growth hormone level. Self-rated anxiety was unaffected in these relatively nonanxious subjects. The diazepam-induced changes in saccadic eye velocity, sedation, and growth hormone and cortisol levels were highly correlated with each other and with increasing plasma diazepam concentration. These results are consistent with a benzodiazepine receptor—mediated action of diazepam. The highly quantifiable and dose-dependent decrease in saccadic eye velocity by benzodiazepines should make this a useful measure of benzodiazepine receptor sensitivity in humans." @default.
- W2068298897 created "2016-06-24" @default.
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- W2068298897 date "1986-06-01" @default.
- W2068298897 modified "2023-10-17" @default.
- W2068298897 title "Benzodiazepine Sensitivity in Normal Human Subjects" @default.
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- W2068298897 doi "https://doi.org/10.1001/archpsyc.1986.01800060032005" @default.
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