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- W2068299435 abstract "An expedient route for semisynthetic para-modified 3′-phenyl docetaxel analogs is described using the initial regioselective iodination of the oxazolidinecarboxylate 3. Palladium catalyzed coupling reactions of the iodo intermediate 4 with alkenyl and aryl boronic acids and alkynes led after alkaline hydrolysis to a series of N,O-protected para-substituted phenylisoserines 6. Coupling with 10-deacetyl-7, 10-O-diTroc-baccatin III followed by standard deprotections and acylation afforded the title analogs." @default.
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- W2068299435 date "1995-04-01" @default.
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- W2068299435 title "Synthesis and biological activity of Para-substituted 3′-phenyl docetaxel analogs" @default.
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