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• W2068302192 abstract "TSH-independent mutant clones (M cells) derived from FRTL5 cells, proliferate vigorously in the absence of TSH. The growth of M cells is stimulated by IGF-I in a dose-dependent fashion, but it is not influenced by TSH. Sm1.2, an antibody against IGF-I cross-reacting with IGF-II, significantly decreases basal DNA synthesis in the M cells. Binding of 125I-IGF-I to M cells is significantly lower than that to FRTL5 cells. M cells produce in their culture medium IGF-like peptides which appear to influence their basal DNA synthesis and the availability of type I receptors to bind exogenous IGF-I." @default.
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• W2068302192 date "1999-04-01" @default.
• W2068302192 modified "2023-09-23" @default.
• W2068302192 title "Endogenous insulin-like growth factors regulate the proliferation of TSH-independent mutants derived from FRTL5 cells" @default.
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• W2068302192 doi "https://doi.org/10.1016/s0300-9084(99)80083-2" @default.
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