Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068303492> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2068303492 endingPage "268" @default.
- W2068303492 startingPage "257" @default.
- W2068303492 abstract "Both antigen- and calcium ionophore A23187-induced airways contractions are dependent on increased concentrations of free intracellular calcium. Antigen, but not A23187, contracted airways in the absence of extracellular calcium, suggesting that antigen-induced airways contraction was partly dependent on the mobilization of intracellular calcium. A series of calcium entry blockers and a calmodulin antagonist were examined on airways contraction induced by antigen, A23187, histamine, and LTD4. Verapamil (10(-5)-3 X 10(-4) M) and nitrendipine (3 X 10(-5)-2.8 X 10(-4) M) dose-dependently inhibited antigen-induced contraction of trachea but only partly inhibited antigen-induced contraction of parenchyma and A23187-induced contractions of both trachea and parenchyma. Lanthanum chloride (up to 10(-4) M) and flunarizine (up to 2.1 X 10(-5) M) were relative ineffective. High concentrations of trifluoperazine (1-3 X 10(-4) M) were necessary to inhibit antigen- and A23187-induced airways contractions. Only verapamil and trifluoperazine were effective inhibitors of the responses to histamine and LTD4. In light of the relative ineffectiveness of the above calcium antagonists on the LTD4 dose-response curves, it is suggested that airways contraction is dependent on mobilization of intracellular calcium and that the action of nitrendipine and verapamil as inhibitors of antigen- and A23187-induced contractions is at the point of blocking mediator (i.e. LTC4 and LTD4) release. Verapamil and trifluoperazine also appear to affect contractions. However, the high concentrations of calcium channel and calmodulin antagonists to inhibit antigen- and A23187-induced contractions may limit their usefulness as anti-allergic, anti-asthmatic agents." @default.
- W2068303492 created "2016-06-24" @default.
- W2068303492 creator A5060039524 @default.
- W2068303492 date "1984-04-01" @default.
- W2068303492 modified "2023-09-23" @default.
- W2068303492 title "Effects of calcium channel blockers and a calmodulin antagonist on contractions of guinea pig airways" @default.
- W2068303492 cites W1500700435 @default.
- W2068303492 cites W1969685305 @default.
- W2068303492 cites W1970723035 @default.
- W2068303492 cites W1981507918 @default.
- W2068303492 cites W1981572906 @default.
- W2068303492 cites W1991712629 @default.
- W2068303492 cites W1993108429 @default.
- W2068303492 cites W1994781325 @default.
- W2068303492 cites W2011985680 @default.
- W2068303492 cites W2024843275 @default.
- W2068303492 cites W2025171723 @default.
- W2068303492 cites W2047397230 @default.
- W2068303492 cites W2047848482 @default.
- W2068303492 cites W2065334680 @default.
- W2068303492 cites W2071892903 @default.
- W2068303492 cites W2081443451 @default.
- W2068303492 cites W2086438889 @default.
- W2068303492 cites W2138973061 @default.
- W2068303492 cites W2163442685 @default.
- W2068303492 cites W2172027701 @default.
- W2068303492 cites W2418613749 @default.
- W2068303492 doi "https://doi.org/10.1016/0014-2999(84)90132-8" @default.
- W2068303492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6428925" @default.
- W2068303492 hasPublicationYear "1984" @default.
- W2068303492 type Work @default.
- W2068303492 sameAs 2068303492 @default.
- W2068303492 citedByCount "17" @default.
- W2068303492 crossrefType "journal-article" @default.
- W2068303492 hasAuthorship W2068303492A5060039524 @default.
- W2068303492 hasConcept C1122143 @default.
- W2068303492 hasConcept C126322002 @default.
- W2068303492 hasConcept C134018914 @default.
- W2068303492 hasConcept C163415756 @default.
- W2068303492 hasConcept C181080969 @default.
- W2068303492 hasConcept C185592680 @default.
- W2068303492 hasConcept C18699975 @default.
- W2068303492 hasConcept C2775891158 @default.
- W2068303492 hasConcept C2777022698 @default.
- W2068303492 hasConcept C2780548744 @default.
- W2068303492 hasConcept C29688787 @default.
- W2068303492 hasConcept C519063684 @default.
- W2068303492 hasConcept C71924100 @default.
- W2068303492 hasConcept C85520022 @default.
- W2068303492 hasConcept C86803240 @default.
- W2068303492 hasConcept C98274493 @default.
- W2068303492 hasConceptScore W2068303492C1122143 @default.
- W2068303492 hasConceptScore W2068303492C126322002 @default.
- W2068303492 hasConceptScore W2068303492C134018914 @default.
- W2068303492 hasConceptScore W2068303492C163415756 @default.
- W2068303492 hasConceptScore W2068303492C181080969 @default.
- W2068303492 hasConceptScore W2068303492C185592680 @default.
- W2068303492 hasConceptScore W2068303492C18699975 @default.
- W2068303492 hasConceptScore W2068303492C2775891158 @default.
- W2068303492 hasConceptScore W2068303492C2777022698 @default.
- W2068303492 hasConceptScore W2068303492C2780548744 @default.
- W2068303492 hasConceptScore W2068303492C29688787 @default.
- W2068303492 hasConceptScore W2068303492C519063684 @default.
- W2068303492 hasConceptScore W2068303492C71924100 @default.
- W2068303492 hasConceptScore W2068303492C85520022 @default.
- W2068303492 hasConceptScore W2068303492C86803240 @default.
- W2068303492 hasConceptScore W2068303492C98274493 @default.
- W2068303492 hasIssue "4" @default.
- W2068303492 hasLocation W20683034921 @default.
- W2068303492 hasLocation W20683034922 @default.
- W2068303492 hasOpenAccess W2068303492 @default.
- W2068303492 hasPrimaryLocation W20683034921 @default.
- W2068303492 hasRelatedWork W1995607250 @default.
- W2068303492 hasRelatedWork W2006668689 @default.
- W2068303492 hasRelatedWork W2012136517 @default.
- W2068303492 hasRelatedWork W2013020409 @default.
- W2068303492 hasRelatedWork W2025590009 @default.
- W2068303492 hasRelatedWork W2068303492 @default.
- W2068303492 hasRelatedWork W2148282970 @default.
- W2068303492 hasRelatedWork W2257026079 @default.
- W2068303492 hasRelatedWork W2383878137 @default.
- W2068303492 hasRelatedWork W2412404567 @default.
- W2068303492 hasVolume "99" @default.
- W2068303492 isParatext "false" @default.
- W2068303492 isRetracted "false" @default.
- W2068303492 magId "2068303492" @default.
- W2068303492 workType "article" @default.