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- W2068303506 abstract "A major constituent of SP in the brains of Alzheimer's disease is 39–43 amino acid peptide called β‐amyloid peptide (Aβ). Recent data have demonstrated that Aβ has a strong tendency to form insoluble aggregates and that toxic effects of Aβ is based on its aggregation. In the current study, 100 µg of human synthetic Aβ 1–42 (sAβ 1–42) was infused into the lateral ventricle of rat brain using a short‐term infusion model. At 2 or 7 days following the infusion, sAβ 1–42 was found to form insoluble aggregates, scattering throughout the entire ventricular systems. The sAβ 1–42 aggregates were partially engulfed by phagocytic cells and deposited at the meningeal vessels or the choroid plexuses. However, these deposits mostly disappeared from the ventricles by 28 days post‐infusion. Here, it is reported for the first time that considerable amounts of sAβ 1–42 are almost cleared from the rat ventricular system by the mononuclear phagocytic system." @default.
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- W2068303506 date "2004-08-27" @default.
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- W2068303506 title "Active clearance of human amyloid beta 1-42 peptide aggregates from the rat ventricular system" @default.
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- W2068303506 doi "https://doi.org/10.1111/j.1440-1789.2004.00549.x" @default.
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