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- W2068313363 abstract "Two new aryl-tetralin lignans, 1 and 2, were isolated from the fruits of Cleistanthus indochinensis by bioassay-guided purification. Their structures were determined by spectroscopic analysis including MS and 2D NMR. The absolute configurations of 1 and 2 were established from examination of their CD spectra. Compound 1 was cytotoxic against KB cells with an IC50 value of 0.022 μM, while compound 2 had weaker cytotoxicity, with an IC50 value of 1.4 μM. When tested against other cancer cell lines (MCF-7, MCF-7R, and HT29), 1 showed an IC50 of 0.014 against MCF-7R cells and an IC50 of 0.036 μM against MCF-7 cells. A series of amide derivatives of a new lactone, homoderivatives of 1, were prepared. Of these derivatives, only compound 3 had weak cytotoxicity against KB cells." @default.
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- W2068313363 date "2012-08-31" @default.
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- W2068313363 title "Cytotoxic Lignans from Fruits of <i>Cleistanthus indochinensis</i>: Synthesis of Cleistantoxin Derivatives" @default.
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- W2068313363 doi "https://doi.org/10.1021/np3003832" @default.
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