FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068320820> ?p ?o ?g. }

• W2068320820 endingPage "157" @default.
• W2068320820 startingPage "149" @default.
• W2068320820 abstract "This study sought to determine whether vascular endothelial growth factor (VEGF)-induced permeabilisation of pulmonary endothelium to macromolecules could be related to a permissive role for neutrophil-derived VEGF in neutrophil transmigration. Treatment of human pulmonary artery endothelial cell (HPAEC) monolayers with 1, 10 or 100 ng/ml VEGF for 15 min or 1, 10 ng/ml for 90 min significantly increased endothelial permeability to trypan blue-labelled albumin (TB-BSA). These increases were correlated with changes in the cellular distribution of F-actin, as visualised by rhodamine–phalloidin staining: increased stress fibre formation, cellular elongation and formation of intercellular gaps after 15 min; at 90 min, there was also evidence of microspike formation and extension of spindle processes from the cell surface. Treatment of human neutrophil suspensions with 200 nM phorbol myristyl acetate (PMA), n-formyl-methionyl leucylphenylalanine (fMLP, 10 nM), interleukin-8 (IL-8, 10 nM) (but not with leukotriene B4 (LTB4) 100 nM), for 30 min caused significant extracellular release of neutrophil VEGF stores. A permissive role for neutrophil-derived VEGF in facilitating migration across HPAEC monolayers was assessed in experiments using a functional blocking antihuman VEGF antibody. In the presence of this antibody (10 μg/ml), neutrophil migration in response to fMLP (10 nM), IL-8 (10 nM) or LTB4 (100 nM) was not significantly different to that in the absence of antibody. We conclude that neutrophil-derived VEGF does not play a functional role in facilitating neutrophil migration across pulmonary vascular endothelium, despite its ability to induce cytoskeletal changes and enhance endothelial macromolecular permeability." @default.
• W2068320820 created "2016-06-24" @default.
• W2068320820 creator A5029298379 @default.
• W2068320820 creator A5048203740 @default.
• W2068320820 creator A5054098944 @default.
• W2068320820 creator A5071237840 @default.
• W2068320820 creator A5074446280 @default.
• W2068320820 date "2000-09-01" @default.
• W2068320820 modified "2023-10-16" @default.
• W2068320820 title "Investigation of vascular endothelial growth factor effects on pulmonary endothelial monolayer permeability and neutrophil transmigration" @default.
• W2068320820 cites W1530655559 @default.
• W2068320820 cites W1604404839 @default.
• W2068320820 cites W1670891845 @default.
• W2068320820 cites W1830906240 @default.
• W2068320820 cites W1893412287 @default.
• W2068320820 cites W1951558217 @default.
• W2068320820 cites W1966931906 @default.
• W2068320820 cites W1970753722 @default.
• W2068320820 cites W1980986856 @default.
• W2068320820 cites W1983407850 @default.
• W2068320820 cites W1988143227 @default.
• W2068320820 cites W1989575428 @default.
• W2068320820 cites W2004159587 @default.
• W2068320820 cites W2011471403 @default.
• W2068320820 cites W2018512891 @default.
• W2068320820 cites W2020738791 @default.
• W2068320820 cites W2020932748 @default.
• W2068320820 cites W2025284114 @default.
• W2068320820 cites W2032941828 @default.
• W2068320820 cites W2035371785 @default.
• W2068320820 cites W2041034845 @default.
• W2068320820 cites W2046371301 @default.
• W2068320820 cites W2047929670 @default.
• W2068320820 cites W2049746210 @default.
• W2068320820 cites W2052286881 @default.
• W2068320820 cites W2056971106 @default.
• W2068320820 cites W2057697484 @default.
• W2068320820 cites W2062121682 @default.
• W2068320820 cites W2062594120 @default.
• W2068320820 cites W2066400861 @default.
• W2068320820 cites W2067313598 @default.
• W2068320820 cites W2075905527 @default.
• W2068320820 cites W2123840402 @default.
• W2068320820 cites W2125297546 @default.
• W2068320820 cites W2149932234 @default.
• W2068320820 cites W2155783433 @default.
• W2068320820 cites W2157280274 @default.
• W2068320820 cites W2158192170 @default.
• W2068320820 cites W2161401312 @default.
• W2068320820 cites W2163287575 @default.
• W2068320820 cites W2202356825 @default.
• W2068320820 cites W2306418883 @default.
• W2068320820 cites W2324588265 @default.
• W2068320820 cites W2331264491 @default.
• W2068320820 cites W2408913661 @default.
• W2068320820 cites W304295984 @default.
• W2068320820 doi "https://doi.org/10.1016/s0306-3623(01)00102-1" @default.
• W2068320820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11744237" @default.
• W2068320820 hasPublicationYear "2000" @default.
• W2068320820 type Work @default.
• W2068320820 sameAs 2068320820 @default.
• W2068320820 citedByCount "21" @default.
• W2068320820 countsByYear W20683208202013 @default.
• W2068320820 countsByYear W20683208202014 @default.
• W2068320820 countsByYear W20683208202015 @default.
• W2068320820 countsByYear W20683208202016 @default.
• W2068320820 countsByYear W20683208202021 @default.
• W2068320820 crossrefType "journal-article" @default.
• W2068320820 hasAuthorship W2068320820A5029298379 @default.
• W2068320820 hasAuthorship W2068320820A5048203740 @default.
• W2068320820 hasAuthorship W2068320820A5054098944 @default.
• W2068320820 hasAuthorship W2068320820A5071237840 @default.
• W2068320820 hasAuthorship W2068320820A5074446280 @default.
• W2068320820 hasConcept C113045295 @default.
• W2068320820 hasConcept C123012128 @default.
• W2068320820 hasConcept C134018914 @default.
• W2068320820 hasConcept C134897094 @default.
• W2068320820 hasConcept C153911025 @default.
• W2068320820 hasConcept C167734588 @default.
• W2068320820 hasConcept C185592680 @default.
• W2068320820 hasConcept C202751555 @default.
• W2068320820 hasConcept C203014093 @default.
• W2068320820 hasConcept C2776685179 @default.
• W2068320820 hasConcept C2776914184 @default.
• W2068320820 hasConcept C2776992346 @default.
• W2068320820 hasConcept C2777025900 @default.
• W2068320820 hasConcept C502942594 @default.
• W2068320820 hasConcept C55493867 @default.
• W2068320820 hasConcept C86803240 @default.
• W2068320820 hasConcept C95444343 @default.
• W2068320820 hasConceptScore W2068320820C113045295 @default.
• W2068320820 hasConceptScore W2068320820C123012128 @default.
• W2068320820 hasConceptScore W2068320820C134018914 @default.
• W2068320820 hasConceptScore W2068320820C134897094 @default.
• W2068320820 hasConceptScore W2068320820C153911025 @default.
• W2068320820 hasConceptScore W2068320820C167734588 @default.
• W2068320820 hasConceptScore W2068320820C185592680 @default.
• W2068320820 hasConceptScore W2068320820C202751555 @default.

• next