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- W2068328049 abstract "D-Homo derivatives in the androstane and estrane series, 12–19, were synthesized by a fragmentation-cyclization reaction of 16-oximino-17-hydroxy-17-substituted derivatives 3–9, or by cyclization of the corresponding D-seco derivatives 20–26. The structures were confirmed by X-ray analysis of compounds 12 and 16. Preliminary assessment of inhibitory effects of D-homo derivatives from androstane series towards aromatase, 3β-hydroxysteroid dehydrogenase (3β-HSD), 17α-hydroxylase/C17-20 lyase (P450c17) and 17β-HSD indicated much lower inhibitory potential compared to previously tested activity of another type of D-modified steroids, namely D-seco derivatives. Also, assessment of potential antiestrogenic activity of derivatives from estrane series showed absence of such an activity." @default.
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- W2068328049 date "2003-09-01" @default.
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- W2068328049 title "Synthesis, X-ray crystal structures and biological activity of 16-amino-17-substituted-D-homo steroid derivatives" @default.
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- W2068328049 doi "https://doi.org/10.1016/s0039-128x(03)00097-7" @default.
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