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• W2068331319 startingPage "3" @default.
• W2068331319 abstract "Significant strides have been made in mammalian cell based biopharmaceutical process and cell line development over the past years. With several established mammalian host cell lines and expression systems, optimization of selection systems to reduce development times and improvement of glycosylation patterns are only some of the advances being made to improve cell culture processes. In this article, the advances pertaining to cell line development and cell engineering strategies are discussed. An overview of the cell engineering strategies to enhance cellular characteristics by genetic manipulation are illustrated, focusing on the use of genomics and proteomics tools and their application in such endeavors. Included in this review are some of the early studies using the ‘omic’ technique to understand cellular mechanisms of product synthesis and secretion, apoptosis, cell proliferation and the influence of the physicochemical environment. The article highlights the significance of integrating genomics and proteomics data with the vast amounts of bioprocess data for improved analysis of the biological pathways involved. Further improvements of the techniques and methodologies used are needed but ultimately, the new cell engineering strategies should provide great insight into the regulatory networks within the cell in a bioprocess environment and how to manipulate them to increase overall productivity." @default.
• W2068331319 created "2016-06-24" @default.
• W2068331319 creator A5023228804 @default.
• W2068331319 creator A5025781518 @default.
• W2068331319 creator A5037097859 @default.
• W2068331319 creator A5061644472 @default.
• W2068331319 date "2007-02-24" @default.
• W2068331319 modified "2023-10-10" @default.
• W2068331319 title "Using cell engineering and omic tools for the improvement of cell culture processes" @default.
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