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- W2068331346 abstract "A new and simple method for the selective condensation of no-carrier-added [11C]nitromethane (1) with various substituted (protected) benzaldehydes to [β−11Cβ-nitrophenethyl alcohols was developed. This method which utilizes tetrabutylammonium fluoride in THF as a catalyst gave a condensation yield of 80–90% and a selectivity of 80–90% for [11C]nitroalcohol vs [11C]nitrostyrene formation within 2 min. Reduction of these [11C]nitroalcohols with Raney nickel in formic acid gave the corresponding [11C]aminoalcohols in a yield of 60–90%. Boron tribromide was used for the cleavage of 4-methoxy and 3,4-(methylenedioxy) phenol protecting groups. After HPLC-purification, racemic 1-11C-labelled norepinephrine (7), phenylethanolamine (4), norphenylephrine (5) and octopamine (6) were prepared in a 12–30% decay corrected total radiochemical yield (20–50% counted from 1) with an overall synthesis time of 40–70 min from end of bombardment (EOB). The radiochemical purity was >98% and the specific radioactivity 700–1500 Ci/mmol (26–56 GBq/μmol)." @default.
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- W2068331346 date "1994-04-01" @default.
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- W2068331346 title "Selective synthesis of racemic 1-11C-labelled norepinephrine, octopamine, norphenylephrine and phenylethanolamine using [11C]nitromethane" @default.
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- W2068331346 doi "https://doi.org/10.1016/0969-8043(94)90117-1" @default.
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