FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068331698> ?p ?o ?g. }

• W2068331698 endingPage "6283" @default.
• W2068331698 startingPage "6274" @default.
• W2068331698 abstract "Abstract We report results from a study exploring the combination of romidepsin, bortezomib, and dexamethasone for the treatment of patients with multiple myeloma (MM) previously treated with > 1 prior therapy. The primary objective was to determine the maximum tolerated dose (MTD) of the combination using a novel accelerated dose-escalation schedule in patients with relapsed or refractory MM. The secondary objective was to determine overall response (OR), time to progression (TTP), and overall survival (OS). The MTD identified was bortezomib 1.3 mg/m2 (days 1, 4, 8, and 11), dexamethasone 20 mg (days 1, 2, 4, 5, 8, 9, 11, and 12), and romidepsin 10 mg/m2 (days 1, 8, and 15) every 28 days. Thrombocytopenia (64%) was the most common ≥ grade 3 hematologic toxicity. Peripheral neuropathy occurred in 76% of patients (n = 19) (≥ grade 3, 8%; 95% confidence interval [CI] 1%-26%). Maintenance romidepsin 10 mg/m2 (on days 1 and 8 of a 28-day cycle) proved feasible, with 12 patients receiving a median of 7.5 cycles (range: 1-29). An OR (M-protein) of > minor response (MR) was seen in 18 of 25 patients (72%); 2 (8%) had complete remissions (CRs) and 13 (52%) had partial responses (PRs), including 7 (28%) with very good PRs (VGPRs). The median TTP was 7.2 (95% CI: 5.5-19.6) months, and the median OS was > 36 months. This regimen shows activity with manageable toxicity and warrants further evaluation. This trial was registered at www.clinicaltrials.gov as NCT00431990." @default.
• W2068331698 created "2016-06-24" @default.
• W2068331698 creator A5015498770 @default.
• W2068331698 creator A5027391845 @default.
• W2068331698 creator A5037352082 @default.
• W2068331698 creator A5039295944 @default.
• W2068331698 creator A5042319853 @default.
• W2068331698 creator A5052829828 @default.
• W2068331698 creator A5078346197 @default.
• W2068331698 creator A5079422749 @default.
• W2068331698 creator A5080478652 @default.
• W2068331698 creator A5081270750 @default.
• W2068331698 creator A5081326206 @default.
• W2068331698 creator A5087634802 @default.
• W2068331698 creator A5091396091 @default.
• W2068331698 date "2011-12-08" @default.
• W2068331698 modified "2023-10-10" @default.
• W2068331698 title "A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma" @default.
• W2068331698 cites W1973120064 @default.
• W2068331698 cites W1978377409 @default.
• W2068331698 cites W1980471295 @default.
• W2068331698 cites W2004558311 @default.
• W2068331698 cites W2010833137 @default.
• W2068331698 cites W2022285476 @default.
• W2068331698 cites W2023351948 @default.
• W2068331698 cites W2044436186 @default.
• W2068331698 cites W2052169053 @default.
• W2068331698 cites W2065327255 @default.
• W2068331698 cites W2080029028 @default.
• W2068331698 cites W2084542540 @default.
• W2068331698 cites W2090317414 @default.
• W2068331698 cites W2095160131 @default.
• W2068331698 cites W2099262276 @default.
• W2068331698 cites W2107154392 @default.
• W2068331698 cites W2107242888 @default.
• W2068331698 cites W2108235071 @default.
• W2068331698 cites W2118335184 @default.
• W2068331698 cites W2120780398 @default.
• W2068331698 cites W2122016142 @default.
• W2068331698 cites W2124560610 @default.
• W2068331698 cites W2129890171 @default.
• W2068331698 cites W2130032361 @default.
• W2068331698 cites W2133739087 @default.
• W2068331698 cites W2139849891 @default.
• W2068331698 cites W2141086589 @default.
• W2068331698 cites W2145412346 @default.
• W2068331698 cites W2156517973 @default.
• W2068331698 cites W2160178966 @default.
• W2068331698 cites W2163564693 @default.
• W2068331698 cites W2169508075 @default.
• W2068331698 cites W2499859474 @default.
• W2068331698 cites W2587332589 @default.
• W2068331698 cites W2589286928 @default.
• W2068331698 cites W2602730924 @default.
• W2068331698 cites W2980059567 @default.
• W2068331698 cites W4245776345 @default.
• W2068331698 cites W4251026461 @default.
• W2068331698 doi "https://doi.org/10.1182/blood-2011-03-339879" @default.
• W2068331698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21911830" @default.
• W2068331698 hasPublicationYear "2011" @default.
• W2068331698 type Work @default.
• W2068331698 sameAs 2068331698 @default.
• W2068331698 citedByCount "71" @default.
• W2068331698 countsByYear W20683316982012 @default.
• W2068331698 countsByYear W20683316982013 @default.
• W2068331698 countsByYear W20683316982014 @default.
• W2068331698 countsByYear W20683316982015 @default.
• W2068331698 countsByYear W20683316982016 @default.
• W2068331698 countsByYear W20683316982017 @default.
• W2068331698 countsByYear W20683316982018 @default.
• W2068331698 countsByYear W20683316982019 @default.
• W2068331698 countsByYear W20683316982020 @default.
• W2068331698 countsByYear W20683316982021 @default.
• W2068331698 countsByYear W20683316982023 @default.
• W2068331698 crossrefType "journal-article" @default.
• W2068331698 hasAuthorship W2068331698A5015498770 @default.
• W2068331698 hasAuthorship W2068331698A5027391845 @default.
• W2068331698 hasAuthorship W2068331698A5037352082 @default.
• W2068331698 hasAuthorship W2068331698A5039295944 @default.
• W2068331698 hasAuthorship W2068331698A5042319853 @default.
• W2068331698 hasAuthorship W2068331698A5052829828 @default.
• W2068331698 hasAuthorship W2068331698A5078346197 @default.
• W2068331698 hasAuthorship W2068331698A5079422749 @default.
• W2068331698 hasAuthorship W2068331698A5080478652 @default.
• W2068331698 hasAuthorship W2068331698A5081270750 @default.
• W2068331698 hasAuthorship W2068331698A5081326206 @default.
• W2068331698 hasAuthorship W2068331698A5087634802 @default.
• W2068331698 hasAuthorship W2068331698A5091396091 @default.
• W2068331698 hasBestOaLocation W20683316981 @default.
• W2068331698 hasConcept C104317684 @default.
• W2068331698 hasConcept C121332964 @default.
• W2068331698 hasConcept C126322002 @default.
• W2068331698 hasConcept C141071460 @default.
• W2068331698 hasConcept C142424586 @default.
• W2068331698 hasConcept C185592680 @default.
• W2068331698 hasConcept C2776364478 @default.
• W2068331698 hasConcept C2777478702 @default.
• W2068331698 hasConcept C2778305200 @default.

• next