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- W2068332602 abstract "Significance Angiogenin is a stress-activated ribonuclease that cleaves tRNA to produce bioactive small noncoding RNAs [tRNA-derived, stress-induced RNAs (tiRNAs)] that function in a cytoprotective stress response program. Point mutations that reduce its ribonuclease activity are found in a subset of patients with ALS, a fatal neurodegenerative disease. We have found that selected tiRNAs assume G-quadruplex (G4) structures that are necessary for cytoprotective and prosurvival functions. Moreover, stable DNA analogs of these G4-containing tiRNAs spontaneously enter motor neurons and confer cytoprotection against stress. Our results identify tiRNAs as leading compounds for the development of a new class of neuroprotective drugs and give insights into the molecular mechanisms underlying the pathobiology of expanded G4-forming hexanucleotide repeats in the C9ORF72 gene." @default.
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- W2068332602 date "2014-11-17" @default.
- W2068332602 modified "2023-10-11" @default.
- W2068332602 title "G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments" @default.
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- W2068332602 doi "https://doi.org/10.1073/pnas.1407361111" @default.
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