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• W2068335282 abstract "<i>Background:</i> The aim of this work was to characterize the relationship between zinc (Zn²⁺) and cadmium (Cd²⁺) and the toxic effects of Cd²⁺ in immortalized renal proximal tubule cells RP1. <i>Methods:</i> An RP1 cell line was developed from primary cultures of microdissected S1 and S2. Uptakes of ⁶⁵Zn and ¹⁰⁹Cd and competitive experiments with Cd²⁺ and Zn²⁺ were performed and kinetic parameters were determined. Oxygen consumption, metallothionein synthesis, and necrotic and apoptotic phenomena were studied. <i>Results:</i> Kinetic parameters indicate that ⁶⁵Zn (Km = 71.8 ± 10.6 µ<i>M</i>) and ¹⁰⁹Cd (Km = 23.3 ± 2.0 µ<i>M</i>) were both transported by a saturable carrier-mediated process. Competition between Cd²⁺ and Zn²⁺ uptake was reciprocal. Cd²⁺ induced an increase in necrosis and apoptosis, and a decrease in oxygen consumption, depending on Cd²⁺ concentrations. Concomitant addition of Zn²⁺ (10 µ<i>M</i>) reduced the number of necrotic and apoptotic cells and maintained oxygen consumption at control levels. Cd²⁺ alone, or in the presence of Zn²⁺, increased metallothionein levels, whereas Zn²⁺ alone did not. <i>Conclusion:</i> Zn²⁺ and Cd²⁺ probably share the same transporter in the proximal tubule. Cd²⁺ caused necrotic and apoptotic cell death. Cd²⁺ toxicity may occur through an effect on the mitochondrial electron transport chain and not on metallothionein synthesis. Zn²⁺ protects against the renal cell toxicity of Cd²⁺." @default.
• W2068335282 created "2016-06-24" @default.
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• W2068335282 date "2005-02-24" @default.
• W2068335282 modified "2023-10-04" @default.
• W2068335282 title "Zinc and Cadmium Interactions in a Renal Cell Line Derived from Rabbit Proximal Tubule" @default.
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• W2068335282 doi "https://doi.org/10.1159/000083413" @default.
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