FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068336213> ?p ?o ?g. }

• W2068336213 endingPage "925" @default.
• W2068336213 startingPage "918" @default.
• W2068336213 abstract "ABSTRACT Slow-growing bacteria and biofilms are notoriously tolerant to antibiotics. Oritavancin is a lipoglycopeptide with multiple mechanisms of action that contribute to its bactericidal action against exponentially growing gram-positive pathogens, including the inhibition of cell wall synthesis and perturbation of membrane barrier function. We sought to determine whether oritavancin could eradicate cells known to be tolerant to many antimicrobial agents, that is, stationary-phase and biofilm cultures of Staphylococcus aureus in vitro. Oritavancin exhibited concentration-dependent bactericidal activity against stationary-phase inocula of methicillin-susceptible S. aureus (MSSA) ATCC 29213, methicillin-resistant S. aureus (MRSA) ATCC 33591, and vancomycin-resistant S. aureus (VRSA) VRS5 inoculated into nutrient-depleted cation-adjusted Mueller-Hinton broth. As has been described for exponential-phase cells, oritavancin induced membrane depolarization, increased membrane permeability, and caused ultrastructural defects including a loss of nascent septal cross walls in stationary-phase MSSA. Furthermore, oritavancin sterilized biofilms of MSSA, MRSA, and VRSA at minimal biofilm eradication concentrations (MBECs) of between 0.5 and 8 μg/ml. Importantly, MBECs for oritavancin were within 1 doubling dilution of their respective planktonic broth MICs, highlighting the potency of oritavancin against biofilms. These results demonstrate a significant activity of oritavancin against S. aureus in phases of growth that exhibit tolerance to other antimicrobial agents." @default.
• W2068336213 created "2016-06-24" @default.
• W2068336213 creator A5023659945 @default.
• W2068336213 creator A5030449858 @default.
• W2068336213 creator A5055581588 @default.
• W2068336213 creator A5056048003 @default.
• W2068336213 creator A5060092452 @default.
• W2068336213 creator A5063290824 @default.
• W2068336213 creator A5087816809 @default.
• W2068336213 creator A5088785560 @default.
• W2068336213 date "2009-03-01" @default.
• W2068336213 modified "2023-10-03" @default.
• W2068336213 title "Oritavancin Kills Stationary-Phase and Biofilm <i>Staphylococcus aureus</i> Cells In Vitro" @default.
• W2068336213 cites W1541430364 @default.
• W2068336213 cites W1587833696 @default.
• W2068336213 cites W1600342134 @default.
• W2068336213 cites W1917216429 @default.
• W2068336213 cites W1977779489 @default.
• W2068336213 cites W1996064131 @default.
• W2068336213 cites W2034443922 @default.
• W2068336213 cites W2038716450 @default.
• W2068336213 cites W2045825103 @default.
• W2068336213 cites W2053696392 @default.
• W2068336213 cites W2061878956 @default.
• W2068336213 cites W2082900223 @default.
• W2068336213 cites W2089663335 @default.
• W2068336213 cites W2091774144 @default.
• W2068336213 cites W2099991997 @default.
• W2068336213 cites W2101752229 @default.
• W2068336213 cites W2106351298 @default.
• W2068336213 cites W2106820870 @default.
• W2068336213 cites W2115499017 @default.
• W2068336213 cites W2115550568 @default.
• W2068336213 cites W2117322493 @default.
• W2068336213 cites W2119197725 @default.
• W2068336213 cites W2128591525 @default.
• W2068336213 cites W2131727615 @default.
• W2068336213 cites W2135655364 @default.
• W2068336213 cites W2137831211 @default.
• W2068336213 cites W2144440398 @default.
• W2068336213 cites W2147723850 @default.
• W2068336213 cites W2151702128 @default.
• W2068336213 cites W2155247629 @default.
• W2068336213 cites W2157265409 @default.
• W2068336213 cites W2157913460 @default.
• W2068336213 cites W2162609209 @default.
• W2068336213 cites W2163581302 @default.
• W2068336213 cites W2168765004 @default.
• W2068336213 cites W4254122983 @default.
• W2068336213 doi "https://doi.org/10.1128/aac.00766-08" @default.
• W2068336213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2650528" @default.
• W2068336213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19104027" @default.
• W2068336213 hasPublicationYear "2009" @default.
• W2068336213 type Work @default.
• W2068336213 sameAs 2068336213 @default.
• W2068336213 citedByCount "153" @default.
• W2068336213 countsByYear W20683362132012 @default.
• W2068336213 countsByYear W20683362132013 @default.
• W2068336213 countsByYear W20683362132014 @default.
• W2068336213 countsByYear W20683362132015 @default.
• W2068336213 countsByYear W20683362132016 @default.
• W2068336213 countsByYear W20683362132017 @default.
• W2068336213 countsByYear W20683362132018 @default.
• W2068336213 countsByYear W20683362132019 @default.
• W2068336213 countsByYear W20683362132020 @default.
• W2068336213 countsByYear W20683362132021 @default.
• W2068336213 countsByYear W20683362132022 @default.
• W2068336213 countsByYear W20683362132023 @default.
• W2068336213 crossrefType "journal-article" @default.
• W2068336213 hasAuthorship W2068336213A5023659945 @default.
• W2068336213 hasAuthorship W2068336213A5030449858 @default.
• W2068336213 hasAuthorship W2068336213A5055581588 @default.
• W2068336213 hasAuthorship W2068336213A5056048003 @default.
• W2068336213 hasAuthorship W2068336213A5060092452 @default.
• W2068336213 hasAuthorship W2068336213A5063290824 @default.
• W2068336213 hasAuthorship W2068336213A5087816809 @default.
• W2068336213 hasAuthorship W2068336213A5088785560 @default.
• W2068336213 hasBestOaLocation W20683362131 @default.
• W2068336213 hasConcept C185592680 @default.
• W2068336213 hasConcept C202751555 @default.
• W2068336213 hasConcept C2779489039 @default.
• W2068336213 hasConcept C4937899 @default.
• W2068336213 hasConcept C523546767 @default.
• W2068336213 hasConcept C54355233 @default.
• W2068336213 hasConcept C55493867 @default.
• W2068336213 hasConcept C58123911 @default.
• W2068336213 hasConcept C86803240 @default.
• W2068336213 hasConcept C89423630 @default.
• W2068336213 hasConceptScore W2068336213C185592680 @default.
• W2068336213 hasConceptScore W2068336213C202751555 @default.
• W2068336213 hasConceptScore W2068336213C2779489039 @default.
• W2068336213 hasConceptScore W2068336213C4937899 @default.
• W2068336213 hasConceptScore W2068336213C523546767 @default.
• W2068336213 hasConceptScore W2068336213C54355233 @default.
• W2068336213 hasConceptScore W2068336213C55493867 @default.
• W2068336213 hasConceptScore W2068336213C58123911 @default.
• W2068336213 hasConceptScore W2068336213C86803240 @default.
• W2068336213 hasConceptScore W2068336213C89423630 @default.

• next