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- W2068337524 abstract "Histone deacetylases (HDACs) play an important role in gene regulation. Inhibitors of HDACs (HDACi) are novel anti-cancer drugs, which induce histone (hyper-) acetylation and counteract aberrant gene repression. On the other hand, HDACi treatment can also result in decreased gene expression, and targeting HDACs affects more than chromatin. Recently, HDACi were shown to evoke non-histone protein acetylation, which can alter signaling networks relevant for tumorgenesis. Furthermore, HDACi can promote the degradation of (proto-) oncoproteins. Here, we summarize these findings and discuss how these substances could be beneficial for the treatment and prevention of human ailments, such as cancer and unbalanced immune functions." @default.
- W2068337524 created "2016-06-24" @default.
- W2068337524 creator A5001180341 @default.
- W2068337524 creator A5010237514 @default.
- W2068337524 creator A5015940174 @default.
- W2068337524 date "2009-08-01" @default.
- W2068337524 modified "2023-09-25" @default.
- W2068337524 title "HDACi – Targets beyond chromatin" @default.
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- W2068337524 doi "https://doi.org/10.1016/j.canlet.2009.02.028" @default.
- W2068337524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19342155" @default.
- W2068337524 hasPublicationYear "2009" @default.
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