FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068337543> ?p ?o ?g. }

• W2068337543 endingPage "1354" @default.
• W2068337543 startingPage "1337" @default.
• W2068337543 abstract "Even in the 21st century, studies aimed at characterizing the pathological paradigms associated with the development and progression of central nervous system diseases are primarily performed in laboratory animals. However, limited translational significance, high cost, and labor to develop the appropriate model (e.g., transgenic or inbred strains) have favored parallel in vitro approaches. In vitro models are of particular interest for cerebrovascular studies of the blood–brain barrier (BBB), which plays a critical role in maintaining the brain homeostasis and neuronal functions. Because the BBB dynamically responds to many events associated with rheological and systemic impairments (e.g., hypoperfusion), including the exposure of potentially harmful xenobiotics, the development of more sophisticated artificial systems capable of replicating the vascular properties of the brain microcapillaries are becoming a major focus in basic, translational, and pharmaceutical research. In vitro BBB models are valuable and easy to use supporting tools that can precede and complement animal and human studies. In this article, we provide a detailed review and analysis of currently available in vitro BBB models ranging from static culture systems to the most advanced flow-based and three-dimensional coculture apparatus. We also discuss recent and perspective developments in this ever expanding research field. Even in the 21st century, studies aimed at characterizing the pathological paradigms associated with the development and progression of central nervous system diseases are primarily performed in laboratory animals. However, limited translational significance, high cost, and labor to develop the appropriate model (e.g., transgenic or inbred strains) have favored parallel in vitro approaches. In vitro models are of particular interest for cerebrovascular studies of the blood–brain barrier (BBB), which plays a critical role in maintaining the brain homeostasis and neuronal functions. Because the BBB dynamically responds to many events associated with rheological and systemic impairments (e.g., hypoperfusion), including the exposure of potentially harmful xenobiotics, the development of more sophisticated artificial systems capable of replicating the vascular properties of the brain microcapillaries are becoming a major focus in basic, translational, and pharmaceutical research. In vitro BBB models are valuable and easy to use supporting tools that can precede and complement animal and human studies. In this article, we provide a detailed review and analysis of currently available in vitro BBB models ranging from static culture systems to the most advanced flow-based and three-dimensional coculture apparatus. We also discuss recent and perspective developments in this ever expanding research field." @default.
• W2068337543 created "2016-06-24" @default.
• W2068337543 creator A5032793820 @default.
• W2068337543 creator A5046655907 @default.
• W2068337543 date "2012-04-01" @default.
• W2068337543 modified "2023-10-12" @default.
• W2068337543 title "In Vitro Blood–Brain Barrier Models: Current and Perspective Technologies" @default.
• W2068337543 cites W1523564114 @default.
• W2068337543 cites W1534057962 @default.
• W2068337543 cites W1548840271 @default.
• W2068337543 cites W1559124240 @default.
• W2068337543 cites W1568597114 @default.
• W2068337543 cites W1581321319 @default.
• W2068337543 cites W1591367548 @default.
• W2068337543 cites W1602831264 @default.
• W2068337543 cites W1622758820 @default.
• W2068337543 cites W16603568 @default.
• W2068337543 cites W1796054280 @default.
• W2068337543 cites W1834747511 @default.
• W2068337543 cites W1942368010 @default.
• W2068337543 cites W1964568221 @default.
• W2068337543 cites W1965838612 @default.
• W2068337543 cites W1965933264 @default.
• W2068337543 cites W1966178564 @default.
• W2068337543 cites W1966481038 @default.
• W2068337543 cites W1967229191 @default.
• W2068337543 cites W1968821998 @default.
• W2068337543 cites W1972282528 @default.
• W2068337543 cites W1972729687 @default.
• W2068337543 cites W1976026884 @default.
• W2068337543 cites W1976439848 @default.
• W2068337543 cites W1976582395 @default.
• W2068337543 cites W1977073394 @default.
• W2068337543 cites W1977291679 @default.
• W2068337543 cites W1977557135 @default.
• W2068337543 cites W1979770296 @default.
• W2068337543 cites W1981175423 @default.
• W2068337543 cites W1982531351 @default.
• W2068337543 cites W1982748428 @default.
• W2068337543 cites W1983512668 @default.
• W2068337543 cites W1984204348 @default.
• W2068337543 cites W1986448801 @default.
• W2068337543 cites W1987969716 @default.
• W2068337543 cites W1990104488 @default.
• W2068337543 cites W1992866322 @default.
• W2068337543 cites W1993192173 @default.
• W2068337543 cites W1993728655 @default.
• W2068337543 cites W1994991276 @default.
• W2068337543 cites W1996086250 @default.
• W2068337543 cites W1996446808 @default.
• W2068337543 cites W1997010751 @default.
• W2068337543 cites W1998359337 @default.
• W2068337543 cites W1998494497 @default.
• W2068337543 cites W1998638899 @default.
• W2068337543 cites W1999190513 @default.
• W2068337543 cites W2000930640 @default.
• W2068337543 cites W2000965529 @default.
• W2068337543 cites W2001267675 @default.
• W2068337543 cites W2003413704 @default.
• W2068337543 cites W2003726414 @default.
• W2068337543 cites W2003974648 @default.
• W2068337543 cites W2004365491 @default.
• W2068337543 cites W2004769086 @default.
• W2068337543 cites W2004926660 @default.
• W2068337543 cites W2009251691 @default.
• W2068337543 cites W2015019057 @default.
• W2068337543 cites W2015541518 @default.
• W2068337543 cites W2016211178 @default.
• W2068337543 cites W2018624702 @default.
• W2068337543 cites W2020554150 @default.
• W2068337543 cites W2021275669 @default.
• W2068337543 cites W2022307232 @default.
• W2068337543 cites W2024170393 @default.
• W2068337543 cites W2027135709 @default.
• W2068337543 cites W2027570733 @default.
• W2068337543 cites W2029541365 @default.
• W2068337543 cites W2030282028 @default.
• W2068337543 cites W2031062821 @default.
• W2068337543 cites W2033756424 @default.
• W2068337543 cites W2034058614 @default.
• W2068337543 cites W2034825883 @default.
• W2068337543 cites W2035669331 @default.
• W2068337543 cites W2036037061 @default.
• W2068337543 cites W2036557993 @default.
• W2068337543 cites W2037931437 @default.
• W2068337543 cites W2040536713 @default.
• W2068337543 cites W2040958998 @default.
• W2068337543 cites W2044660208 @default.
• W2068337543 cites W2045228120 @default.
• W2068337543 cites W2045454822 @default.
• W2068337543 cites W2045755433 @default.
• W2068337543 cites W2046662414 @default.
• W2068337543 cites W2046826638 @default.
• W2068337543 cites W2047075745 @default.
• W2068337543 cites W2050285850 @default.
• W2068337543 cites W2051188685 @default.
• W2068337543 cites W2053963421 @default.
• W2068337543 cites W2059368790 @default.

• next