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• W2068343452 abstract "To investigate the correlation between normalization of T cell receptor (TCR) repertoire and remission of advanced colorectal cancer. Forty‐one patients were randomly assigned to receive either folinic acid/fluorouracil/irinotecan alone ( n = 20) or folinic acid/fluorouracil/irinotecan in combination with recombinant human endostatin ( n = 21). Efficacy and toxicity were evaluated, and changes in TCR repertoire diversity were assessed by detecting the spectratypes of TCR complementarity‐determining region three before and after several cycles of therapy. A scoring system was used to quantify changes in the TCR repertoire over time. The results demonstrated that the TCR repertoire exhibited a higher degree of normalization among patients undergoing remission relative to patients experiencing tumor progression. The results of the current study showed a positive correlation between TCR repertoire normalization and remission of colorectal cancer, suggesting that dynamic monitoring of TCR repertoire diversity may have potential prognostic value in the clinical setting. ( Cancer Sci 2011; 102: 706–712)" @default.
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• W2068343452 date "2011-02-20" @default.
• W2068343452 modified "2023-10-17" @default.
• W2068343452 title "Normalization of T cell receptor repertoire diversity in patients with advanced colorectal cancer who responded to chemotherapy" @default.
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• W2068343452 doi "https://doi.org/10.1111/j.1349-7006.2011.01868.x" @default.
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