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• W2068346070 abstract "No AccessJournal of UrologyInvestigative Urology1 May 1996Photodynamic Therapy on Rat Urinary Bladder with Intravesical Instillation of 5-Aminolevulinic Acid: Light Diffusion and Histological Changes Shi-Chung Chang, Alexander J. MacRobert, and Stephen G. Bown Shi-Chung ChangShi-Chung Chang Dr. Chang is funded by the Compassion Relief of Tzu-Chi Foundation in Taiwan. Professor Bown is supported by the Imperial Cancer Research Fund, United Kingdom. More articles by this author , Alexander J. MacRobertAlexander J. MacRobert More articles by this author , and Stephen G. BownStephen G. Bown More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66191-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Photodynamic therapy (PDT) has the potential to treat extensive premalignant lesions and microinvasive tumors in the bladder, but its use has been hampered by the risk of detrusor muscle damage and prolonged skin photosensitivity. We have shown that the rat urothelium can be sensitized by selectively using a 10 percent solution of 5-aminolevulinic acid (ALA) at pH 5.5 administered intravesically. This paper evaluates the photodynamic effects on sensitized bladders. Materials and Methods: The bladders of Wistar rats were instilled with ALA solutions of different concentrations at pH 5.5 and subsequently treated with laser light at 630 nm. Bladders were harvested 1 to 7 days after PDT for histological assessment. Results: Under optimum conditions (10 percent intralipid diffusion medium, light dose 50J) uniform urothelial necrosis was seen after 1 to 2 days; it healed in 7 days without damage to the underlying muscle layer although some increase in collagen was seen in the lamina propria. Overtreatment or poor light distribution resulted in muscle necrosis and scarring. Conclusions: Selective urothelial necrosis is possible with PDT using intravesical ALA. There is now sufficient data for pilot clinical trials to start photodynamic therapy for management of superficial bladder cancer or carcinoma in situ. References 1 : Photosensitized oxidation and singlet oxygen: consequences in biological systems. In: . Edited by . New York: Academic Press1976: 85. Google Scholar 2 : Hematoporphyrin derivative: a possible aid in the diagnosis and therapy of carcinoma of the bladder. J. Urol1976; 115: 150. 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Link, Google Scholar National Medical Laser Centre, University College London Medical School, England, and Tz'u-Chi General Hospital, Hua-Lien, Taiwan.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBaig M, Miocinovic R, Keck R, Fynes E, Strobel S, Kropp K and Selman S (2018) Replacement of Intestinal Mucosa With Urothelium in Rat Augmented Bladders Using Intravesical Photodynamic Therapy With 5-Aminolaevulinic AcidJournal of Urology, VOL. 178, NO. 3, (1108-1112), Online publication date: 1-Sep-2007.XIAO Z, BROWN K, TULIP J and MOORE R (2018) Whole Bladder Photodynamic Therapy for Orthotopic Superficial Bladder Cancer in Rats: A Study of Intravenous and Intravesical Administration of PhotosensitizersJournal of Urology, VOL. 169, NO. 1, (352-356), Online publication date: 1-Jan-2003.MARTI A, JICHLINSKI P, LANGE N, BALLINI J, GUILLOU L, LEISINGER H and KUCERA P (2018) Comparison of Aminolevulinic Acid and Hexylester Aminolevulinate Induced Protoporphyrin IX Distribution in Human Bladder CancerJournal of Urology, VOL. 170, NO. 2, (428-432), Online publication date: 1-Aug-2003.WAIDELICH R, STEPP H, BAUMGARTNER R, WENINGER E, HOFSTETTER A and KRIEGMAIR M (2018) CLINICAL EXPERIENCE WITH 5-AMINOLEVULINIC ACID AND PHOTODYNAMIC THERAPY FOR REFRACTORY SUPERFICIAL BLADDER CANCERJournal of Urology, VOL. 165, NO. 6 Part 1, (1904-1907), Online publication date: 1-Jun-2001. Volume 155Issue 5May 1996Page: 1749-1753 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Shi-Chung Chang Dr. Chang is funded by the Compassion Relief of Tzu-Chi Foundation in Taiwan. Professor Bown is supported by the Imperial Cancer Research Fund, United Kingdom. More articles by this author Alexander J. MacRobert More articles by this author Stephen G. Bown More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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