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- W2068346616 abstract "Basal and modulated secretion of PRL and GH by dispersed cell cultures of human somatotropic, lactotropic, and mixed somatotropic-lactotropic adenomas has been examined. Twenty-four-hour secretion of PRL by a normal pituitary, a lactotropic, and a mixed adenoma increased with time in culture. The secretion rate from a mixed adenoma had increased 18-fold by day 20 over that observed on day 1, 225 µg PRL being produced from 4 X 105 cells. PRL secretion was still elevated after 36 days of culture. GH secretion always decreased rapidly from day 1. Initial GH secretion in cultures of a somatotropic adenoma was 18-fold of that from the same number of normal pituitary cells. Theophylline (10-2 M) significantly stimulated GH secretion by somatotropic and mixed adenoma cells during a 4-h incubation after 4 and 28, but not 49, days in culture. PRL secretion was only stimulated at 28 days. TRH stimulated PRL and GH secretion from adenomas in a dose-dependent manner, with 10 ng/ml TRH being maximal. Somatostatin alon..." @default.
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- W2068346616 date "1979-07-01" @default.
- W2068346616 modified "2023-09-27" @default.
- W2068346616 title "Hormone Secretion by Dispersed Cell Cultures of Human Pituitary Adenomas: Effects of Theophylline, Thyrotropin-Releasing Hormone, Somatostatin, and 2-Bromo-α-Ergocryptine*" @default.
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- W2068346616 doi "https://doi.org/10.1210/jcem-49-1-120" @default.
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