FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068348545> ?p ?o ?g. }

• W2068348545 endingPage "711" @default.
• W2068348545 startingPage "700" @default.
• W2068348545 abstract "The conclusions of studies to date which evaluate a possible association between factor V Leiden and adverse pregnancy outcome have been conflicting. This study was undertaken to further investigate this association. Our objective was to evaluate the association between adverse pregnancy outcomes and maternal factor V Leiden genotype by meta-analysis. Inclusion criteria were: (a) cohort or case control design; (b) outcomes clearly defined as one of the following: first or second/ third trimester miscarriage or intrauterine death, preeclampsia, fetal growth retardation, or placental abruption; (c) both the case and control mothers tested for the factor V Leiden mutation; (d) sufficient data for calculation of an odds ratio. Both fixed and random effect models were used to pool results and heterogeneity and publication bias were checked. For first trimester fetal loss, the pooled odds ratio was heterogeneous (p=0.06) and no dose-response curve could be found. For second/third trimester fetal loss, there was a consistent and graded increase in risk: the odds ratio was 2.4 (95% CI 1.1-5.2) for isolated (non-recurrent) third trimester fetal loss, rising to 10.7 (95% CI 4.0-28.5) for those with 2 or more second/third trimester fetal losses. Factor V Leiden is associated with a 2.9 fold (95% CI 2.0-4.3) increased risk of severe preeclampsia, and a 4.8 fold (95% CI 2.4-9.4) increased risk of fetal growth retardation. These results support factor V Leiden testing for women with recurrent fetal loss in the second/third trimester. Women with only 1 event may also warrant testing if the fetal loss occurred in the third trimester. Conversely, in those women known to have the factor V Leiden mutation, monitoring for adverse pregnancy outcomes is warranted; whether this means increased vigilance or anti-coagulant prophylaxis is still contentious." @default.
• W2068348545 created "2016-06-24" @default.
• W2068348545 creator A5064342997 @default.
• W2068348545 creator A5089051246 @default.
• W2068348545 date "2004-01-01" @default.
• W2068348545 modified "2023-10-14" @default.
• W2068348545 title "The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis" @default.
• W2068348545 cites W1258952978 @default.
• W2068348545 cites W1524603322 @default.
• W2068348545 cites W1589820399 @default.
• W2068348545 cites W1836479959 @default.
• W2068348545 cites W1837804097 @default.
• W2068348545 cites W1866816235 @default.
• W2068348545 cites W1888308189 @default.
• W2068348545 cites W19183810 @default.
• W2068348545 cites W1943918823 @default.
• W2068348545 cites W1965958910 @default.
• W2068348545 cites W1966451334 @default.
• W2068348545 cites W1966559901 @default.
• W2068348545 cites W1970051571 @default.
• W2068348545 cites W1970312914 @default.
• W2068348545 cites W1970442833 @default.
• W2068348545 cites W1972058538 @default.
• W2068348545 cites W1976957654 @default.
• W2068348545 cites W1980250272 @default.
• W2068348545 cites W1980427744 @default.
• W2068348545 cites W1982105326 @default.
• W2068348545 cites W1990556266 @default.
• W2068348545 cites W1991118253 @default.
• W2068348545 cites W1992208561 @default.
• W2068348545 cites W1994709901 @default.
• W2068348545 cites W1998015660 @default.
• W2068348545 cites W1999459044 @default.
• W2068348545 cites W2004673917 @default.
• W2068348545 cites W2004860469 @default.
• W2068348545 cites W2007274113 @default.
• W2068348545 cites W2007765785 @default.
• W2068348545 cites W2008480721 @default.
• W2068348545 cites W2009964192 @default.
• W2068348545 cites W2010893661 @default.
• W2068348545 cites W2013155340 @default.
• W2068348545 cites W2018973645 @default.
• W2068348545 cites W2019390804 @default.
• W2068348545 cites W2023219983 @default.
• W2068348545 cites W2025281452 @default.
• W2068348545 cites W2026882731 @default.
• W2068348545 cites W2039494231 @default.
• W2068348545 cites W2040250767 @default.
• W2068348545 cites W2041511477 @default.
• W2068348545 cites W2043663172 @default.
• W2068348545 cites W2046103305 @default.
• W2068348545 cites W2047147853 @default.
• W2068348545 cites W2048319059 @default.
• W2068348545 cites W2049332602 @default.
• W2068348545 cites W2050564041 @default.
• W2068348545 cites W2051848324 @default.
• W2068348545 cites W2053457999 @default.
• W2068348545 cites W2062411855 @default.
• W2068348545 cites W2062994753 @default.
• W2068348545 cites W2071378775 @default.
• W2068348545 cites W2073923860 @default.
• W2068348545 cites W2079929930 @default.
• W2068348545 cites W2085151281 @default.
• W2068348545 cites W2101226231 @default.
• W2068348545 cites W2102185245 @default.
• W2068348545 cites W2103886741 @default.
• W2068348545 cites W2110797618 @default.
• W2068348545 cites W2116355717 @default.
• W2068348545 cites W2119742619 @default.
• W2068348545 cites W2121539145 @default.
• W2068348545 cites W2121950342 @default.
• W2068348545 cites W2125909495 @default.
• W2068348545 cites W2136152362 @default.
• W2068348545 cites W2140735246 @default.
• W2068348545 cites W2145533041 @default.
• W2068348545 cites W2150491173 @default.
• W2068348545 cites W2151257471 @default.
• W2068348545 cites W2154778977 @default.
• W2068348545 cites W2155668548 @default.
• W2068348545 cites W2157580106 @default.
• W2068348545 cites W2158042435 @default.
• W2068348545 cites W2171453022 @default.
• W2068348545 cites W2273197846 @default.
• W2068348545 cites W2287792823 @default.
• W2068348545 cites W2312867046 @default.
• W2068348545 cites W2329963748 @default.
• W2068348545 cites W2395732527 @default.
• W2068348545 cites W2412848516 @default.
• W2068348545 cites W2416066480 @default.
• W2068348545 cites W77078003 @default.
• W2068348545 doi "https://doi.org/10.1160/th03-10-0637" @default.
• W2068348545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15045131" @default.
• W2068348545 hasPublicationYear "2004" @default.
• W2068348545 type Work @default.
• W2068348545 sameAs 2068348545 @default.
• W2068348545 citedByCount "109" @default.
• W2068348545 countsByYear W20683485452012 @default.
• W2068348545 countsByYear W20683485452013 @default.

• next