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• W2068352564 endingPage "1343" @default.
• W2068352564 startingPage "1333" @default.
• W2068352564 abstract "Alterations in receptor expression and distribution between cell surface and cytoplasm are means by which psychostimulants regulate neurotransmission. Metabotropic glutamate receptor group I, subtype 5 (mGluR5) and GABA(B) receptors (GABA(B) R) are critically involved in the development and expression of stimulant-induced behaviors, including conditioned place preference (CPP), an index of drug-seeking. However, it is not known if psychostimulant-induced CPP alters the trafficking of these receptors. To fill this gap, this study used methamphetamine (Meth)-induced CPP in rats to ascertain if receptor changes occur in limbic brain regions that regulate drug-seeking, the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and ventral pallidum (VP). To do so, ex vivo tissue was assessed for changes in expression and surface vs. intracellular distribution of mGluR5 and GABA(B) Rs. There was a decrease in the surface to intracellular ratio of mGluR5 in the mPFC in Meth-conditioned rats, commensurate with an increase in intracellular levels. mGluR5 levels in the NAc or the VP were unaltered. There were no changes for GABA(B) R in any brain region assayed. This ex vivo snapshot of metabotropic glutamate and GABA receptor cellular distribution following induction of Meth-induced CPP is the first report to determine if these receptors are differentially altered after Meth-induced CPP. The results suggest that this Meth treatment paradigm likely induced a compensatory change in mGluR5 surface to intracellular ratio such that the surface remains unaltered while an increase in intracellular protein occurred." @default.
• W2068352564 created "2016-06-24" @default.
• W2068352564 creator A5060334059 @default.
• W2068352564 creator A5068781763 @default.
• W2068352564 creator A5074594625 @default.
• W2068352564 date "2011-08-31" @default.
• W2068352564 modified "2023-10-09" @default.
• W2068352564 title "Brain region-selective cellular redistribution of mGlu5 but not GABAB receptors following methamphetamine-induced associative learning" @default.
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• W2068352564 doi "https://doi.org/10.1002/syn.20968" @default.
• W2068352564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21780181" @default.
• W2068352564 hasPublicationYear "2011" @default.
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