FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068353403> ?p ?o ?g. }

• W2068353403 abstract "Demyelination is a pathological process characterized by the loss of myelin around axons. In the central nervous system, oligodendroglial damage and demyelination are common pathological features characterizing white matter and neurodegenerative disorders. Remyelination is a regenerative process by which myelin sheaths are restored to demyelinated axons, resolving functional deficits. This process is often deficient in demyelinating diseases such as multiple sclerosis (MS), and the reasons for the failure of repair mechanisms remain unclear. The characterization of these mechanisms and the factors involved in the proliferation, recruitment, and differentiation of oligodendroglial progenitor cells is key in designing strategies to improve remyelination in demyelinating disorders. First, a very dynamic combination of different molecules such as growth factors, cytokines, chemokines, and different signaling pathways is tightly regulated during the remyelination process. Second, factors unrelated to this pathology, i.e., age and genetic background, may impact disease progression either positively or negatively, and in particular, age-related remyelination failure has been proven to involve oligodendroglial cells aging and their intrinsic capacities among other factors. Third, nutrients may either help or hinder disease progression. Experimental evidence supports the anti-inflammatory role of omega-6 and omega-3 polyunsaturated fatty acids through the competitive inhibition of arachidonic acid, whose metabolites participate in inflammation, and the reduction in T cell proliferation. In turn, vitamin D intake and synthesis have been associated with lower MS incidence levels, while vitamin D-gene interactions might be involved in the pathogenesis of MS. Finally, dietary polyphenols have been reported to mitigate demyelination by modulating the immune response." @default.
• W2068353403 created "2016-06-24" @default.
• W2068353403 creator A5013800720 @default.
• W2068353403 date "2013-12-06" @default.
• W2068353403 modified "2023-10-11" @default.
• W2068353403 title "Nutritional factors and aging in demyelinating diseases" @default.
• W2068353403 cites W151443056 @default.
• W2068353403 cites W159791013 @default.
• W2068353403 cites W1679478585 @default.
• W2068353403 cites W1960757861 @default.
• W2068353403 cites W1964106067 @default.
• W2068353403 cites W1966395272 @default.
• W2068353403 cites W1967726276 @default.
• W2068353403 cites W1969905245 @default.
• W2068353403 cites W1972725262 @default.
• W2068353403 cites W1974465663 @default.
• W2068353403 cites W1976139504 @default.
• W2068353403 cites W1976415863 @default.
• W2068353403 cites W1978825269 @default.
• W2068353403 cites W1981117271 @default.
• W2068353403 cites W1984891852 @default.
• W2068353403 cites W1986330452 @default.
• W2068353403 cites W1994662145 @default.
• W2068353403 cites W1995494321 @default.
• W2068353403 cites W1997801717 @default.
• W2068353403 cites W1999745515 @default.
• W2068353403 cites W2001434128 @default.
• W2068353403 cites W2002061934 @default.
• W2068353403 cites W2006387377 @default.
• W2068353403 cites W2012294621 @default.
• W2068353403 cites W2013304151 @default.
• W2068353403 cites W2016210371 @default.
• W2068353403 cites W2017395674 @default.
• W2068353403 cites W2017655089 @default.
• W2068353403 cites W2021786345 @default.
• W2068353403 cites W2022380830 @default.
• W2068353403 cites W2023367024 @default.
• W2068353403 cites W2027711440 @default.
• W2068353403 cites W2035098555 @default.
• W2068353403 cites W2037456020 @default.
• W2068353403 cites W2038757125 @default.
• W2068353403 cites W2040143503 @default.
• W2068353403 cites W2044654272 @default.
• W2068353403 cites W2048082433 @default.
• W2068353403 cites W2053814423 @default.
• W2068353403 cites W2055241344 @default.
• W2068353403 cites W2057037962 @default.
• W2068353403 cites W2057361877 @default.
• W2068353403 cites W2058236762 @default.
• W2068353403 cites W2058718560 @default.
• W2068353403 cites W2063305853 @default.
• W2068353403 cites W2063639010 @default.
• W2068353403 cites W2065621953 @default.
• W2068353403 cites W2066356973 @default.
• W2068353403 cites W2068629398 @default.
• W2068353403 cites W2072451119 @default.
• W2068353403 cites W2077978097 @default.
• W2068353403 cites W2080256179 @default.
• W2068353403 cites W2083551906 @default.
• W2068353403 cites W2083772330 @default.
• W2068353403 cites W2084324436 @default.
• W2068353403 cites W2084380425 @default.
• W2068353403 cites W2085879860 @default.
• W2068353403 cites W2089295489 @default.
• W2068353403 cites W2089866074 @default.
• W2068353403 cites W2094044389 @default.
• W2068353403 cites W2100119722 @default.
• W2068353403 cites W2103161616 @default.
• W2068353403 cites W2105844486 @default.
• W2068353403 cites W2111256919 @default.
• W2068353403 cites W2113672425 @default.
• W2068353403 cites W2122665472 @default.
• W2068353403 cites W2123453097 @default.
• W2068353403 cites W2126574528 @default.
• W2068353403 cites W2136230791 @default.
• W2068353403 cites W2139485237 @default.
• W2068353403 cites W2140560855 @default.
• W2068353403 cites W2143890525 @default.
• W2068353403 cites W2144540270 @default.
• W2068353403 cites W2146288654 @default.
• W2068353403 cites W2148839576 @default.
• W2068353403 cites W2150752337 @default.
• W2068353403 cites W2154861644 @default.
• W2068353403 cites W2158064024 @default.
• W2068353403 cites W2158151457 @default.
• W2068353403 cites W2158156478 @default.
• W2068353403 cites W2162465757 @default.
• W2068353403 cites W2162523489 @default.
• W2068353403 cites W2165506482 @default.
• W2068353403 cites W2425811051 @default.
• W2068353403 cites W242594513 @default.
• W2068353403 doi "https://doi.org/10.1007/s12263-013-0360-8" @default.
• W2068353403 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3896619" @default.
• W2068353403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24311441" @default.
• W2068353403 hasPublicationYear "2013" @default.
• W2068353403 type Work @default.
• W2068353403 sameAs 2068353403 @default.
• W2068353403 citedByCount "18" @default.
• W2068353403 countsByYear W20683534032014 @default.
• W2068353403 countsByYear W20683534032015 @default.

• next