Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068357714> ?p ?o ?g. }
- W2068357714 abstract "ABSTRACT In addition to providing information on tissue structure, magnetic resonance (MR) technology offers the potential to investigate tissue metabolism and function. MR spectroscopy (MRS) offers a wealth of data on the biochemistry of a selected brain tissue volume, which represent potential surrogate markers for the pathology underlying multiple sclerosis (MS). In particular, the N ‐acetylaspartate peak in an MR spectrum is a putative marker of neuronal and axonal integrity, and the choline peak appears to reflect cell‐membrane metabolism. On this basis, a diminished N ‐acetylaspartate peak is interpreted to represent neuronal/axonal dysfunction or loss, and an elevated choline peak represents heightened cell‐membrane turnover, as seen in demyelination, remyelination, inflammation, or gliosis. Therefore, MRS may provide a unique tool to evaluate the severity of MS, establish a prognosis, follow disease evolution, understand its pathogenesis, and evaluate the efficacy of therapeutic interventions, which complements the information obtained from the various forms of assessment made by conventional MR imaging." @default.
- W2068357714 created "2016-06-24" @default.
- W2068357714 creator A5040227234 @default.
- W2068357714 date "2005-10-01" @default.
- W2068357714 modified "2023-10-10" @default.
- W2068357714 title "Magnetic Resonance Spectroscopy in the Monitoring of Multiple Sclerosis" @default.
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- W2068357714 doi "https://doi.org/10.1177/1051228405284200" @default.
- W2068357714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1351238" @default.
- W2068357714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16385018" @default.
- W2068357714 hasPublicationYear "2005" @default.
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