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- W2068357844 abstract "<h2>Abstract</h2> Since bombesin is widely distributed in the gastrointestinal tract and releases gastrin, it may play a physiological role in gastric acid secretion. We compared the effects of an anticholinergic drug, atropine, and a cholinomimetic drug, bethanecol, on gastric release caused by bombesin and by a mixed meal in dogs. Atropine slightly enhanced the gastrin responses to both stimuli. Bethanecol had no effect on food-stimulated gastrin release, but markedly diminished the gastrin response to bombesin. Gastrin release by bombesin appeared to be inhibited by antral acidification. When food and bombesin were given together, the gastrin response was increased in an additive fashion with no evidence for potentiation. The present data provide no evidence for a role of bombesin in food-stimulated gastrin release. However, it could participate in the neural release of gastrin that has been shown previously to be enhanced by small doses of atropine in man." @default.
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- W2068357844 date "1980-06-01" @default.
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- W2068357844 title "Mechanisms of gastrin release by bombesin and food" @default.
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- W2068357844 doi "https://doi.org/10.1016/0022-4804(80)90046-3" @default.
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