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- W2068358617 abstract "In order to fabricate a kind of amphiphilic hot-melt pressure sensitive adhesives (HMPSAs) suitable for transdermal drug delivery systems (TDDS) of natural medicines, SIS-based hot-melt pressure sensitive adhesives were modified by a melt-blending method, in which a kind of hydrophilic poly (ethyl acrylate-co-methyl methacrylate-co-trimethylammonioethyl methacrylate chloride) (RLPO) and polyethylene glycol 2000 (PEG2000) were utilized. Functional RLPO and its plasticizer PEG2000 worked as a hydrophilic skeleton of amphiphilic HMPSAs. SEM and FT-IR results indicated that RLPO and SIS were partially compatible with each other through n-π complex between the n electrons of the carbonyl group of RLPO and the π electrons of the benzene rings of SIS and their compound had a good thermal stability. The phase microscope images showed that PEG could improve the compatibility between RLPO phase and SIS phase. As the ratio of SIS/RLPO/PEG equaled to 1/2/1.6, their compounds obtained bi-continuous structures. Geniposide (logP<0) and oleanic acid (logP=9.0) were chosen as representatives of hydrophilic drugs and lipophilic drugs, respectively. It was observed that both hydrophilic drugs and lipophilic drugs had a continuous release in the optimized amphiphilic HMPSAs. In addition, the release behavior of hydrophilic geniposide could be controlled by adjusting the ratio of RLPO to PEG." @default.
- W2068358617 created "2016-06-24" @default.
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- W2068358617 date "2013-09-01" @default.
- W2068358617 modified "2023-10-16" @default.
- W2068358617 title "Studies on <i>In Vitro</i> Release Performance of Hydrophilic Drugs and Lipophilic Drugs in Amphiphilic SIS-Based Hot-Melt Pressure Sensitive Adhesives" @default.
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- W2068358617 doi "https://doi.org/10.4028/www.scientific.net/amm.395-396.389" @default.
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